TY - JOUR
T1 - Vaginosis-associated bacteria and its association with HPV infection
AU - Romero-Morelos, Pablo
AU - Bandala, Cindy
AU - Jiménez-Tenorio, Julián
AU - Valdespino-Zavala, Mariana
AU - Rodríguez-Esquivel, Miriam
AU - Gama-Ríos, Reyna Anaid
AU - Bandera, Artfy
AU - Mendoza-Rodríguez, Mónica
AU - Taniguchi, Keiko
AU - Marrero-Rodríguez, Daniel
AU - López-Romero, Ricardo
AU - Ramón-Gallegos, Eva
AU - Salcedo, Mauricio
N1 - Publisher Copyright:
© 2018 Elsevier España, S.L.U.
PY - 2019/1/4
Y1 - 2019/1/4
N2 - Background and objective: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. Material and methods: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history. All samples were screened for Atopobium vaginae, Gardnerella vaginalis and HPV by PCR. Results: High HPV prevalence was found in precursor samples, and 30% of samples without lesions were positive for HPV. Virtually all samples contained sequences of both bacteria, and interestingly, there was not HPV association observed; these results could suggest that these microorganisms could be part of the cervical microbiome in Mexican population. Conclusions: The results obtained indicate that the bacteria analysed could be part of normal biome in Mexican women, suggesting a potential reconsideration of the pathogen role of these microorganisms.
AB - Background and objective: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. Material and methods: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history. All samples were screened for Atopobium vaginae, Gardnerella vaginalis and HPV by PCR. Results: High HPV prevalence was found in precursor samples, and 30% of samples without lesions were positive for HPV. Virtually all samples contained sequences of both bacteria, and interestingly, there was not HPV association observed; these results could suggest that these microorganisms could be part of the cervical microbiome in Mexican population. Conclusions: The results obtained indicate that the bacteria analysed could be part of normal biome in Mexican women, suggesting a potential reconsideration of the pathogen role of these microorganisms.
KW - Atopobium vaginae
KW - Bacterial vaginosis
KW - Cervical cancer
KW - Gardnerella vaginalis
KW - Human papilloma virus
UR - http://www.scopus.com/inward/record.url?scp=85043368038&partnerID=8YFLogxK
U2 - 10.1016/j.medcli.2018.01.027
DO - 10.1016/j.medcli.2018.01.027
M3 - Artículo
C2 - 29544661
SN - 0025-7753
VL - 152
SP - 1
EP - 5
JO - Medicina Clinica
JF - Medicina Clinica
IS - 1
ER -