TY - JOUR
T1 - Trypanosoma cruzi connatal transmission in dogs with chagas disease
T2 - Experimental case report
AU - Rodríguez-Morales, Olivia
AU - Ballinas-Verdugo, Martha A.
AU - Alejandre-Aguilar, Ricardo
AU - Reyes, Pedro A.
AU - Arce-Fonseca, Minerva
PY - 2011/10/1
Y1 - 2011/10/1
N2 - Trypanosoma cruzi connatal transmission was studied in male and female mongrel dogs. Both dogs were experimentally infected, after which on the 20 th day, lymphoadenomegaly and fever were found. Four months postinfection, they mated. At this time, Chagas disease was confirmed by two different diagnostic tests. The electrocardiogram and echocardiogram taken at the eight postinoculation month showed data consistent with ischemia, local conduction abnormalities and hypertrophy, as well as a diminished ejection fraction and left ventricular dilation, respectively. Four puppies were born and after weaning had weakness, progressive weight loss, and chronic diarrhea. Necropsy of all four showed digestive alterations and cardiac dilation. Serology in the offspring was positive for Chagas disease. The histopathological study demonstrated a cardiac chronic inflammatory process, although no parasites were found. Clinical data and serological determinations are consistent with death from advanced Chagas disease.
AB - Trypanosoma cruzi connatal transmission was studied in male and female mongrel dogs. Both dogs were experimentally infected, after which on the 20 th day, lymphoadenomegaly and fever were found. Four months postinfection, they mated. At this time, Chagas disease was confirmed by two different diagnostic tests. The electrocardiogram and echocardiogram taken at the eight postinoculation month showed data consistent with ischemia, local conduction abnormalities and hypertrophy, as well as a diminished ejection fraction and left ventricular dilation, respectively. Four puppies were born and after weaning had weakness, progressive weight loss, and chronic diarrhea. Necropsy of all four showed digestive alterations and cardiac dilation. Serology in the offspring was positive for Chagas disease. The histopathological study demonstrated a cardiac chronic inflammatory process, although no parasites were found. Clinical data and serological determinations are consistent with death from advanced Chagas disease.
KW - Canine model
KW - Chagas disease
KW - Domestic animal
KW - Trypanosoma cruzi
KW - Vertical transmission
UR - http://www.scopus.com/inward/record.url?scp=80053640758&partnerID=8YFLogxK
U2 - 10.1089/vbz.2010.0231
DO - 10.1089/vbz.2010.0231
M3 - Artículo
C2 - 21973028
SN - 1530-3667
VL - 11
SP - 1365
EP - 1370
JO - Vector-Borne and Zoonotic Diseases
JF - Vector-Borne and Zoonotic Diseases
IS - 10
ER -