TY - JOUR
T1 - Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative
AU - Bandala, Cindy
AU - Cárdenas-Rodríguez, Noemi
AU - Reyes-Long, Samuel
AU - Cortes-Altamirano, José Luis
AU - Garciadiego-Cázares, David
AU - Lara-Padilla, Eleazar
AU - Ibáñez-Cervantes, Gabriela
AU - Mancilla-Ramírez, Javier
AU - Gómez-Manzo, Saul
AU - Alfaro-Rodríguez, Alfonso
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases. Neuroinflammation or gliosis in patients with obesity and type 2 diabetes mellitus has been related to the effect of adipokines, high lipid levels and glucose, which increase the production of free radicals. Cerebral gliosis can be a risk factor for developing neurodegenerative diseases, and antioxidants could be an alternative for the prevention and treatment of neural comorbidities in obese patients. Aim: Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation. Method: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management. Conclusion: Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.
AB - Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases. Neuroinflammation or gliosis in patients with obesity and type 2 diabetes mellitus has been related to the effect of adipokines, high lipid levels and glucose, which increase the production of free radicals. Cerebral gliosis can be a risk factor for developing neurodegenerative diseases, and antioxidants could be an alternative for the prevention and treatment of neural comorbidities in obese patients. Aim: Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation. Method: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management. Conclusion: Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.
KW - antioxidants
KW - comorbidities
KW - free radicals
KW - gliosis
KW - neuroinflammation
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85140489873&partnerID=8YFLogxK
U2 - 10.3390/antiox11101972
DO - 10.3390/antiox11101972
M3 - Artículo de revisión
C2 - 36290695
AN - SCOPUS:85140489873
SN - 2076-3921
VL - 11
JO - Antioxidants
JF - Antioxidants
IS - 10
M1 - 1972
ER -
