TY - JOUR
T1 - Toxicology of antimicrobial nanoparticles for prosthetic devices
AU - Nuñez-Anita, Rosa Elvira
AU - Acosta-Torres, Laura Susana
AU - Vilar-Pineda, Jorge
AU - Martínez-Espinosa, Juan Carlos
AU - de la Fuente-Hernández, Javier
AU - Castaño, Víctor Manuel
PY - 2014/8/20
Y1 - 2014/8/20
N2 - Advances in nanotechnology are producing an accelerated proliferation of new nanomaterial composites that are likely to become an important source of engineered health-related products. Nanoparticles with antifungal effects are of great interest in the formulation of microbicidal materials. Fungi are found as innocuous commensals and colonize various habitats in and on humans, especially the skin and mucosa. As growth on surfaces is a natural part of the Candida spp. lifestyle, one can expect that Candida organisms colonize prosthetic devices, such as dentures. Macromolecular systems, due to their properties, allow efficient use of these materials in various fields, including the creation of reinforced nanoparticle polymers with antimicrobial activity. This review briefly summarizes the results of studies conducted during the past decade and especially in the last few years focused on the toxicity of different antimicrobial polymers and factors influencing their activities, as well as the main applications of antimicrobial polymers in dentistry. The present study addresses aspects that are often overlooked in nanotoxicology studies, such as careful time-dependent characterization of agglomeration and ion release.
AB - Advances in nanotechnology are producing an accelerated proliferation of new nanomaterial composites that are likely to become an important source of engineered health-related products. Nanoparticles with antifungal effects are of great interest in the formulation of microbicidal materials. Fungi are found as innocuous commensals and colonize various habitats in and on humans, especially the skin and mucosa. As growth on surfaces is a natural part of the Candida spp. lifestyle, one can expect that Candida organisms colonize prosthetic devices, such as dentures. Macromolecular systems, due to their properties, allow efficient use of these materials in various fields, including the creation of reinforced nanoparticle polymers with antimicrobial activity. This review briefly summarizes the results of studies conducted during the past decade and especially in the last few years focused on the toxicity of different antimicrobial polymers and factors influencing their activities, as well as the main applications of antimicrobial polymers in dentistry. The present study addresses aspects that are often overlooked in nanotoxicology studies, such as careful time-dependent characterization of agglomeration and ion release.
KW - Antifungal effect
KW - Cytotoxicity
KW - Dentistry
KW - Denture bases
KW - Genotoxicity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84929990105&partnerID=8YFLogxK
U2 - 10.2147/IJN.S63064
DO - 10.2147/IJN.S63064
M3 - Artículo de revisión
SN - 1176-9114
VL - 9
SP - 3999
EP - 4006
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
IS - 1
ER -