TY - JOUR
T1 - TiO2@SiO2 nanoparticles functionalized with para-aminobenzoic acid (PABA) by Fisher esterification reaction
AU - Carrera-Jota, María L.
AU - García-Hernández, Margarita
AU - Rivera-Becerril, Ernesto
AU - Luna-Domínguez, Jorge H.
AU - Ángel de, J. Morales Ramírez
AU - López-Marure, Arturo
AU - López-Camacho, Perla Y.
AU - González-Penguelly, Brenely
N1 - Publisher Copyright:
©2019 The Japan Institute of Metals and Materials.
PY - 2019
Y1 - 2019
N2 - In this work, hybrid TiO2 nanoparticles embedded in SiO2 were obtained by means of sol-gel process, testing different proportions of the silicon and titanium oxides to obtain TiO2 particles with a high surface content of hydroxyl groups. Anatase crystalline form of TiO2 is a widely used material in active-substance release studies, due to its optimal properties for the transport, distribute and release of different molecules into biological systems. According to the X-ray diffraction analysis, all the proportions of evaluated hybrid systems presented the anatase phase, however, the molar proportion (20:80, TiO2:SiO2) contains a high quantity of hydroxyl groups according to infrared spectroscopy. The spherical morphology of the particles were observed by scanning electron microscopy forming agglomerates. The functionalization of these surfaces was carried out using para-aminobenzoic acid as a drug-binding model that generated a covalent bond between the TiO2@SiO2 system, likewise, thermogravimetric analysis identified the content of functionalized PABA. Dynamic light scattering showed particles and agglomerates around 25609 nm and negative value of zeta (¦)-potential in the molar ratio TiO2:SiO2 20:80-PABA. Finally, we demonstrated that PABA hydrolyzes in the presence of human plasma, recovering the nanoparticularized systems with the hydroxyl groups. The hydroxyl groups on the particle surface promote the incorporation of organic molecules that contain carboxyl groups in their structure.
AB - In this work, hybrid TiO2 nanoparticles embedded in SiO2 were obtained by means of sol-gel process, testing different proportions of the silicon and titanium oxides to obtain TiO2 particles with a high surface content of hydroxyl groups. Anatase crystalline form of TiO2 is a widely used material in active-substance release studies, due to its optimal properties for the transport, distribute and release of different molecules into biological systems. According to the X-ray diffraction analysis, all the proportions of evaluated hybrid systems presented the anatase phase, however, the molar proportion (20:80, TiO2:SiO2) contains a high quantity of hydroxyl groups according to infrared spectroscopy. The spherical morphology of the particles were observed by scanning electron microscopy forming agglomerates. The functionalization of these surfaces was carried out using para-aminobenzoic acid as a drug-binding model that generated a covalent bond between the TiO2@SiO2 system, likewise, thermogravimetric analysis identified the content of functionalized PABA. Dynamic light scattering showed particles and agglomerates around 25609 nm and negative value of zeta (¦)-potential in the molar ratio TiO2:SiO2 20:80-PABA. Finally, we demonstrated that PABA hydrolyzes in the presence of human plasma, recovering the nanoparticularized systems with the hydroxyl groups. The hydroxyl groups on the particle surface promote the incorporation of organic molecules that contain carboxyl groups in their structure.
KW - Functionalization
KW - Hybrid nanoparticles
KW - PABA
KW - Sol-gel
UR - http://www.scopus.com/inward/record.url?scp=85071488412&partnerID=8YFLogxK
U2 - 10.2320/matertrans.M2019085
DO - 10.2320/matertrans.M2019085
M3 - Artículo
AN - SCOPUS:85071488412
SN - 1345-9678
VL - 60
SP - 2033
EP - 2040
JO - Materials Transactions
JF - Materials Transactions
IS - 9
ER -