TY - JOUR
T1 - Time course of angiotensin II dependent vascular and metabolic effects of preeclampsia
AU - Rosas, Paula
AU - Tufiño, Cecilia
AU - Bracho Valdes, Ismael
AU - Bobadilla Lugo, Rosa A.
N1 - Publisher Copyright:
© 2017 International Society for the Study of Hypertension in Pregnancy
PY - 2017/10
Y1 - 2017/10
N2 - Pregnancy is characterized by a blunted pressor response to angiotensin II that is progressively lost during preeclampsia complicated pregnancies. Renin angiotensin system (RAS) plays a pivotal role in cardiovascular and renal function but its role in normal and pathological pregnancy is far from being clarified. It is not as clear if hypertension and particularly pregnancy-induced hypertension as the initial event, can trigger some of the metabolic syndrome components, and if these changes are angiotensin II mediated. The aim of this study was to determine the time course of angiotensin II contribution to the vascular and eventual metabolic changes of preeclampsia. An experimental model was developed by reducing feto-placental circulation through a subrenal aorta coarctation before pregnancy in rats. Control and pregnant (preeclamptic) animals were treated with captopril (5 mg/kg po) or saline solution for 21, 14 or 7 days before delivery, and their body weight, plasma glucose and blood pressure were registered. Phenylephrine (Phe) induced contraction was evaluated using isolated aorta rings. Preeclampsia increased blood pressure (2nd and 3rd wk) but also weight (3rd wk) and glucose values (2nd and 3rd week). Captopril (for 21 or 14 days) treatment prevented increases in blood pressure and plasma glucose but not in body weight. Also, captopril treatment significantly increased aorta contractility. These results provide evidence that cardiovascular and metabolic disturbances of preeclampsia appear simultaneously and are angiotensin II dependent.
AB - Pregnancy is characterized by a blunted pressor response to angiotensin II that is progressively lost during preeclampsia complicated pregnancies. Renin angiotensin system (RAS) plays a pivotal role in cardiovascular and renal function but its role in normal and pathological pregnancy is far from being clarified. It is not as clear if hypertension and particularly pregnancy-induced hypertension as the initial event, can trigger some of the metabolic syndrome components, and if these changes are angiotensin II mediated. The aim of this study was to determine the time course of angiotensin II contribution to the vascular and eventual metabolic changes of preeclampsia. An experimental model was developed by reducing feto-placental circulation through a subrenal aorta coarctation before pregnancy in rats. Control and pregnant (preeclamptic) animals were treated with captopril (5 mg/kg po) or saline solution for 21, 14 or 7 days before delivery, and their body weight, plasma glucose and blood pressure were registered. Phenylephrine (Phe) induced contraction was evaluated using isolated aorta rings. Preeclampsia increased blood pressure (2nd and 3rd wk) but also weight (3rd wk) and glucose values (2nd and 3rd week). Captopril (for 21 or 14 days) treatment prevented increases in blood pressure and plasma glucose but not in body weight. Also, captopril treatment significantly increased aorta contractility. These results provide evidence that cardiovascular and metabolic disturbances of preeclampsia appear simultaneously and are angiotensin II dependent.
KW - Angiotensin II receptors
KW - Glucose metabolism
KW - Preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=85020836212&partnerID=8YFLogxK
U2 - 10.1016/j.preghy.2017.06.005
DO - 10.1016/j.preghy.2017.06.005
M3 - Artículo
C2 - 29153690
SN - 2210-7789
VL - 10
SP - 51
EP - 56
JO - Pregnancy Hypertension
JF - Pregnancy Hypertension
ER -