TY - JOUR
T1 - The sigma factor SigD of Mycobacterium tuberculosis putatively enhances gene expression of the septum site determining protein under stressful environments
AU - Ares, Miguel A.
AU - Rios-Sarabia, Nora
AU - De La Cruz, Miguel A.
AU - Rivera-Gutierrez, Sandra
AU - Garcia-Morales, Lazaro
AU - Leon-Solis, Lizbel
AU - Espitia, Clara
AU - Pacheco, Sabino
AU - Cerna-Cortes, Jorge F.
AU - Helguera-Repetto, A. Cecilia
AU - Garcia, Maria Jesus
AU - Gonzalez-y-Merchand, Jorge A.
N1 - Publisher Copyright:
© 2017 by EDIMES - Edizioni Internazionali Srl. All rights reserved.
PY - 2017/7
Y1 - 2017/7
N2 - This work examined the expression of the septum site determining gene (ssd) of Mycobacterium tuberculosis CDC1551 and its ΔsigD mutant under different growing conditions. The results showed an up-regulation of ssd during stationary phase and starvation conditions, but not during in vitro dormancy, suggesting a putative role for SigD in the control of ssd expression mainly under lack-of-nutrients environments. Furthermore, we elucidated a putative link between ssd expression and cell elongation of bacilli at stationary phase. In addition, a -35 sigD consensus sequence was found for the ssd promoter region, reinforcing the putative regulation of ssd by SigD, and in turn, supporting this protein role during the adaptation of M. tuberculosis to some stressful environments.
AB - This work examined the expression of the septum site determining gene (ssd) of Mycobacterium tuberculosis CDC1551 and its ΔsigD mutant under different growing conditions. The results showed an up-regulation of ssd during stationary phase and starvation conditions, but not during in vitro dormancy, suggesting a putative role for SigD in the control of ssd expression mainly under lack-of-nutrients environments. Furthermore, we elucidated a putative link between ssd expression and cell elongation of bacilli at stationary phase. In addition, a -35 sigD consensus sequence was found for the ssd promoter region, reinforcing the putative regulation of ssd by SigD, and in turn, supporting this protein role during the adaptation of M. tuberculosis to some stressful environments.
KW - M. tuberculosis
KW - Septum site determining protein
KW - SigD
KW - Stressful environments
KW - Type IV pili
UR - http://www.scopus.com/inward/record.url?scp=85029808141&partnerID=8YFLogxK
M3 - Artículo
SN - 1121-7138
VL - 40
SP - 199
EP - 204
JO - New Microbiologica
JF - New Microbiologica
IS - 3
ER -