TY - JOUR
T1 - The network of transcriptional interactions imposes linear constrains in the genome
AU - Menchaca-Mendez, Ricardo
AU - Janga, Sarath Chandra
AU - Collado-Vides, Julio
PY - 2005
Y1 - 2005
N2 - Two prokaryotic organisms for which transcriptional regulatory interactions have been well elucidated by experimental means are Escherichia coli and Bacillus subtilis. Here we show, with the help of simulations and from known data, the importance of proximity of the transcription factor gene and the respective regulated gene in regulatory networks. We discuss the importance of the location of external sensing machinery close to the genes for transcription factors that regulate them in light of our finding.
AB - Two prokaryotic organisms for which transcriptional regulatory interactions have been well elucidated by experimental means are Escherichia coli and Bacillus subtilis. Here we show, with the help of simulations and from known data, the importance of proximity of the transcription factor gene and the respective regulated gene in regulatory networks. We discuss the importance of the location of external sensing machinery close to the genes for transcription factors that regulate them in light of our finding.
UR - http://www.scopus.com/inward/record.url?scp=22044453999&partnerID=8YFLogxK
U2 - 10.1089/omi.2005.9.139
DO - 10.1089/omi.2005.9.139
M3 - Artículo
SN - 1536-2310
VL - 9
SP - 139
EP - 145
JO - OMICS A Journal of Integrative Biology
JF - OMICS A Journal of Integrative Biology
IS - 2
ER -