TY - JOUR
T1 - The D543N polymorphism of the SLC11A1/NRAMP1 gene is associated with treatment failure in male patients with pulmonary tuberculosis
AU - Salinas-Delgado, Yvain
AU - Galaviz-Hernández, Carlos
AU - Toral, René García
AU - Ávila Rejón, Carmen A.
AU - Reyes-Lopez, Miguel A.
AU - Martínez, Antonio Rojas
AU - Martínez-Aguilar, Gerardo
AU - Sosa-Macías, Martha
N1 - Publisher Copyright:
© 2015 by De Gruyter 2015.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: Polymorphisms in SLC11A1/NRAMP1 have shown an important association with susceptibility to tuberculosis and progression to active disease. However, whether there is an association of these polymorphisms with treatment failure is unknown. The aim of this study was to determine the association of SLC11A1 polymorphisms with treatment failure in Mexican subjects with pulmonary tuberculosis. Methods: Thirty-three subjects with treatment failure were paired by age and body mass index with 33 patients who successfully completed treatment and were considered cured. We assessed the polymorphisms of SLC11A1 in the regions of D543N and INT4 via polymerase chain reaction real-time TaqMan® single nucleotide polymorphism (SNP) genotyping. Results: We found that D543N (G/A genotype) was associated with treatment failure in patients with pulmonary tuberculosis [odds ratio (OR) 11.61, 95% confidence interval (CI) 3.66-36.78]. When adjusted by gender, this association remained significant in males (OR 11.09, 95% CI 3.46-35.51). Conclusions: In our male population, the presence of the D543N polymorphism of SLC11A1 is a risk factor for treatment failure. This finding should be confirmed in other populations.
AB - Background: Polymorphisms in SLC11A1/NRAMP1 have shown an important association with susceptibility to tuberculosis and progression to active disease. However, whether there is an association of these polymorphisms with treatment failure is unknown. The aim of this study was to determine the association of SLC11A1 polymorphisms with treatment failure in Mexican subjects with pulmonary tuberculosis. Methods: Thirty-three subjects with treatment failure were paired by age and body mass index with 33 patients who successfully completed treatment and were considered cured. We assessed the polymorphisms of SLC11A1 in the regions of D543N and INT4 via polymerase chain reaction real-time TaqMan® single nucleotide polymorphism (SNP) genotyping. Results: We found that D543N (G/A genotype) was associated with treatment failure in patients with pulmonary tuberculosis [odds ratio (OR) 11.61, 95% confidence interval (CI) 3.66-36.78]. When adjusted by gender, this association remained significant in males (OR 11.09, 95% CI 3.46-35.51). Conclusions: In our male population, the presence of the D543N polymorphism of SLC11A1 is a risk factor for treatment failure. This finding should be confirmed in other populations.
KW - SLC11A1/NRAMP1
KW - pulmonary tuberculosis
KW - treatment failure
UR - http://www.scopus.com/inward/record.url?scp=84941099397&partnerID=8YFLogxK
U2 - 10.1515/dmpt-2015-0019
DO - 10.1515/dmpt-2015-0019
M3 - Artículo
C2 - 26353180
SN - 2363-8907
VL - 30
SP - 211
EP - 214
JO - Drug Metabolism and Personalized Therapy
JF - Drug Metabolism and Personalized Therapy
IS - 3
ER -