TY - JOUR
T1 - The alternative NADH dehydrogenase is present in mitochondria of some animal taxa
AU - Matus-Ortega, MacArio Genaro
AU - Salmerón-Santiago, Karina Gabriela
AU - Flores-Herrera, Oscar
AU - Guerra-Sánchez, Guadalupe
AU - Martínez, Federico
AU - Rendón, Juan Luis
AU - Pardo, Juan Pablo
N1 - Funding Information:
This work was supported by Consejo Nacional de Ciencia y Tecnología ( CONACyT 59855 ) and Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica ( PAPIIT IN219107-3 ), Universidad Nacional Autónoma de México (UNAM) . This work is part of the Ph.D. studies of Matus-Ortega MG in the Doctorado de Ciencias Biomédicas, Universidad Nacional Autónoma de México. We also thank a referee for the suggestion of the third evolutionary scenario, and the insightful suggestions raised by the more recent referees which resulted in the improvement of the manuscript.
PY - 2011/9
Y1 - 2011/9
N2 - The distribution of the alternative NADH dehydrogenase (NDH-2) in the living world was explored. The enzyme, although present in representatives of all living kingdoms, does not have a universal distribution. With the exception of ε-proteobacteria, the enzyme was found in all eubacterial groups. In contrast with the known presence of the NDH-2 in Archaea, the alternative oxidase (AOX) is absent in this group. With regard to the Eukarya domain, the NDH-2 was found in representatives of Protista, Fungi, Plantae, and Animalia. In the latter, however, the presence of the enzyme was restricted to some primitive Metazoa (Placozoa and Cnidaria), and two members of the Deuterostomate lineage of the Bilateria (Echinodermata and Urochordata). No evidence for the presence of the NDH-2 was found in any representative of the Protostomate branch of the Bilateria, contrasting with the existence of the AOX in this same group. It is worth mentioning that those animal species containing the NDH-2 also have an AOX. The actual distribution of the NDH-2 in the various living kingdoms is discussed within the framework of the endosymbiotic theory; in addition, a hypothesis is proposed to explain the disappearance of the alternative NDH-2 and AOX from the majority of the animals.
AB - The distribution of the alternative NADH dehydrogenase (NDH-2) in the living world was explored. The enzyme, although present in representatives of all living kingdoms, does not have a universal distribution. With the exception of ε-proteobacteria, the enzyme was found in all eubacterial groups. In contrast with the known presence of the NDH-2 in Archaea, the alternative oxidase (AOX) is absent in this group. With regard to the Eukarya domain, the NDH-2 was found in representatives of Protista, Fungi, Plantae, and Animalia. In the latter, however, the presence of the enzyme was restricted to some primitive Metazoa (Placozoa and Cnidaria), and two members of the Deuterostomate lineage of the Bilateria (Echinodermata and Urochordata). No evidence for the presence of the NDH-2 was found in any representative of the Protostomate branch of the Bilateria, contrasting with the existence of the AOX in this same group. It is worth mentioning that those animal species containing the NDH-2 also have an AOX. The actual distribution of the NDH-2 in the various living kingdoms is discussed within the framework of the endosymbiotic theory; in addition, a hypothesis is proposed to explain the disappearance of the alternative NDH-2 and AOX from the majority of the animals.
KW - Alternative NADH dehydrogenase
KW - Evolution
KW - Metazoa
KW - Type II NADH dehydrogenase
UR - http://www.scopus.com/inward/record.url?scp=80052035464&partnerID=8YFLogxK
U2 - 10.1016/j.cbd.2011.05.002
DO - 10.1016/j.cbd.2011.05.002
M3 - Artículo
C2 - 21632289
AN - SCOPUS:80052035464
SN - 1744-117X
VL - 6
SP - 256
EP - 263
JO - Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics
JF - Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics
IS - 3
ER -