TY - JOUR
T1 - Tert-butylhydroquinone pretreatment protects kidney from ischemia-reperfusion injury
AU - Guerrero-Beltrán, Carlos E.
AU - Tapia, Edilia
AU - Sánchez-González, Dolores J.
AU - Martínez-Martínez, Claudia M.
AU - Cristobal-García, Magdalena
AU - Pedraza-Chaverri, José
PY - 2012/2
Y1 - 2012/2
N2 - Background: It is generally accepted that an excessive production of reactive oxygen species plays an important role in acute renal failure secondary to ischemia and reperfusion. tert-Butylhydroquinone (tBHQ) is a well-known antioxidant. In this study, we evaluated whether tBHQ pretreatment prevented renal damage induced by ischemia and reperfusion (I/R). Methods: Four groups of rats were studied: (a) controlsham (CT), (b) tBHQ-sham (tBHQ), (c) I/R and (d) tBHQ + I/R. Intraperitoneal (i.p.) injections of tBHQ (50 mg/ kg) were given to the tBHQ and tBHQ + I/R groups and 3% ethanol/isotonic saline solution to the CT and I/R groups. Animals were killed 24 hours after I/R. Results: tBHQ attenuated I/R-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion and the decrease in several antioxidant enzymes. Conclusion: The renoprotective effect of tBHQ on I/R injury was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes.
AB - Background: It is generally accepted that an excessive production of reactive oxygen species plays an important role in acute renal failure secondary to ischemia and reperfusion. tert-Butylhydroquinone (tBHQ) is a well-known antioxidant. In this study, we evaluated whether tBHQ pretreatment prevented renal damage induced by ischemia and reperfusion (I/R). Methods: Four groups of rats were studied: (a) controlsham (CT), (b) tBHQ-sham (tBHQ), (c) I/R and (d) tBHQ + I/R. Intraperitoneal (i.p.) injections of tBHQ (50 mg/ kg) were given to the tBHQ and tBHQ + I/R groups and 3% ethanol/isotonic saline solution to the CT and I/R groups. Animals were killed 24 hours after I/R. Results: tBHQ attenuated I/R-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion and the decrease in several antioxidant enzymes. Conclusion: The renoprotective effect of tBHQ on I/R injury was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes.
KW - Antioxidant enzymes
KW - Ischemia-reperfusion
KW - Oxidative stress
KW - Renoprotection
UR - http://www.scopus.com/inward/record.url?scp=84862259745&partnerID=8YFLogxK
U2 - 10.5301/JN.2011.8345
DO - 10.5301/JN.2011.8345
M3 - Artículo
C2 - 21607921
SN - 1121-8428
VL - 25
SP - 84
EP - 89
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 1
ER -