EVALUATION TERATOLOGIQUE DE L'∅-ASARONE CHEZ LE RAT

L. Jimenez, G. Chamorro, M. Salazar, N. Pages

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9 Citas (Scopus)

Resumen

The fetotoxic potential of orally administered α-asarone was evaluated in Wistar pregnant rats given 0-25-50 and 75 mg/kg between day 6 and day 15 of gestation. The fetuses were removed for examination on day 20. A significant maternal toxicity, as indicated by reduced weight gain, was observed among pregnant dams given 50 and 75 mg/kg/day of the test material. Embryotoxic effects appeared also in the two highest treated groups, represented by the numbers of mothers and fetuses affected. However, in the 75 mg/kg treated group, significantly reduced number of fetuses per litter and decreased fetal body weights were observed.

Título traducido de la contribuciónTeratological evaluation of α-asarone in rats
Idioma originalFrancés
Páginas (desde-hasta)179-183
Número de páginas5
PublicaciónAnnales Pharmaceutiques Francaises
Volumen46
N.º3
EstadoPublicada - 1988

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