Resumen
The fetotoxic potential of orally administered α-asarone was evaluated in Wistar pregnant rats given 0-25-50 and 75 mg/kg between day 6 and day 15 of gestation. The fetuses were removed for examination on day 20. A significant maternal toxicity, as indicated by reduced weight gain, was observed among pregnant dams given 50 and 75 mg/kg/day of the test material. Embryotoxic effects appeared also in the two highest treated groups, represented by the numbers of mothers and fetuses affected. However, in the 75 mg/kg treated group, significantly reduced number of fetuses per litter and decreased fetal body weights were observed.
Título traducido de la contribución | Teratological evaluation of α-asarone in rats |
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Idioma original | Francés |
Páginas (desde-hasta) | 179-183 |
Número de páginas | 5 |
Publicación | Annales Pharmaceutiques Francaises |
Volumen | 46 |
N.º | 3 |
Estado | Publicada - 1988 |