TY - JOUR
T1 - Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells
AU - Sixto-López, Yudibeth
AU - Marhuenda, Emilie
AU - García-Vazquez, Juan Benjamin
AU - Fragoso-Vazquez, Manuel Jonathan
AU - Rosales-Hernández, Martha Cecilia
AU - Zacarías-Lara, Oscar
AU - Méndez-Luna, David
AU - Gómez-Vidal, José Antonio
AU - Cornu, David
AU - Norbert, Bakalara
AU - Correa-Basurto, José
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/8
Y1 - 2022/8
N2 - Glioblastoma multiforme (GBM) is account for 70% of all primary malignancies of the central nervous system. The median survival of human patients after treatment is around 15 months. There are several biological targets which have been reported that can be pursued using ligands with varied structures to treat this disease. In our group, we have developed several ligands that target a wide range of proteins involved in anticancer effects, such as histone deacetylase (HDACs), G protein-coupled estrogen receptor 1 (GPER), estrogen receptor-beta (ERβ) and NADPH oxidase (NOX), that were screened on bidimensional (2D) and tridimensional (3D) GBM stem cells like (GSC). Our results show that some HDAC inhibitors show antiproliferative properties at 21–32 µM. These results suggest that in this 3D culture, HDACs could be the most relevant targets that are modulated to induce the antiproliferative effects that require in the future further experimental studies.
AB - Glioblastoma multiforme (GBM) is account for 70% of all primary malignancies of the central nervous system. The median survival of human patients after treatment is around 15 months. There are several biological targets which have been reported that can be pursued using ligands with varied structures to treat this disease. In our group, we have developed several ligands that target a wide range of proteins involved in anticancer effects, such as histone deacetylase (HDACs), G protein-coupled estrogen receptor 1 (GPER), estrogen receptor-beta (ERβ) and NADPH oxidase (NOX), that were screened on bidimensional (2D) and tridimensional (3D) GBM stem cells like (GSC). Our results show that some HDAC inhibitors show antiproliferative properties at 21–32 µM. These results suggest that in this 3D culture, HDACs could be the most relevant targets that are modulated to induce the antiproliferative effects that require in the future further experimental studies.
KW - 3D cell culture
KW - ER
KW - GPER
KW - Glioblastoma multiforme
KW - HDAC
KW - NOX
UR - http://www.scopus.com/inward/record.url?scp=85102737597&partnerID=8YFLogxK
U2 - 10.1007/s10571-021-01072-9
DO - 10.1007/s10571-021-01072-9
M3 - Artículo
C2 - 33740172
AN - SCOPUS:85102737597
SN - 0272-4340
VL - 42
SP - 1909
EP - 1920
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
IS - 6
ER -