TY - JOUR
T1 - Tabebuia rosea (Bertol.) DC. ethanol extract attenuates body weight gain by activation of molecular mediators associated with browning
AU - Pagaza-Straffon, Elsa Cecilia
AU - Mezo-González, Carla Elena
AU - Chavaro-Pérez, David Armando
AU - Cornejo-Garrido, Jorge
AU - Marchat, Laurence A.
AU - Benítez-Cardoza, Claudia G.
AU - Anaya-Reyes, Maricruz
AU - Ordaz-Pichardo, Cynthia
N1 - Publisher Copyright:
© 2021
PY - 2021/11
Y1 - 2021/11
N2 - Tabebuia rosea has been reported to have anti-cancer, antioxidant, and hypoglycemic activities, and other species of the same genus have anti-obesity effect. Ethanol extract of T. rosea (TrEtOH) produced a significant decrease in body weight (12.1%), and a diminution in lipid profile markers in high fat diet-induced obese C57BL/6 mice. A reduction in the number of hypertrophic adipocytes and a decrease of triglycerides was observed in adipose tissue, added to a reduction in size and fat in hepatocytes. The administration of TrEtOH leads to the mRNA overexpression of UCP1, TBX1, and GLUT4, suggesting that the extract promotes adipocyte browning as a possible mechanism of action. A glycosylated coumarin, lapachol and quercetin were quantified in TrEtOH extract. Interestingly TrEtOH extract did not show mutagenicity, genotoxicity, or toxic effects after acute or 28 days repeated administration. TrEtOH extract could be used for the development of new drugs against obesity and its comorbidities.
AB - Tabebuia rosea has been reported to have anti-cancer, antioxidant, and hypoglycemic activities, and other species of the same genus have anti-obesity effect. Ethanol extract of T. rosea (TrEtOH) produced a significant decrease in body weight (12.1%), and a diminution in lipid profile markers in high fat diet-induced obese C57BL/6 mice. A reduction in the number of hypertrophic adipocytes and a decrease of triglycerides was observed in adipose tissue, added to a reduction in size and fat in hepatocytes. The administration of TrEtOH leads to the mRNA overexpression of UCP1, TBX1, and GLUT4, suggesting that the extract promotes adipocyte browning as a possible mechanism of action. A glycosylated coumarin, lapachol and quercetin were quantified in TrEtOH extract. Interestingly TrEtOH extract did not show mutagenicity, genotoxicity, or toxic effects after acute or 28 days repeated administration. TrEtOH extract could be used for the development of new drugs against obesity and its comorbidities.
KW - Browning
KW - Obesity
KW - Polyphenols
KW - Tabebuia rosea
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85114696407&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2021.104740
DO - 10.1016/j.jff.2021.104740
M3 - Artículo
AN - SCOPUS:85114696407
SN - 1756-4646
VL - 86
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 104740
ER -