TY - JOUR
T1 - Synthesis and characterization of two danazol derivatives
AU - Figueroa-Valverde, Lauro
AU - Díaz-Cedillo, Francisco
AU - López-Ramos, Maria
AU - Garcia-Cervera, Elodia
PY - 2010/12
Y1 - 2010/12
N2 - Two danazol derivatives were synthesized and characterized by spectral analyses. In order to characterize the structural and chemical requirements of danazol derivatives, several parameters such as logP, π, Rm and Vm were evaluated. The results showed an increase in the values of logP for the compound 6 in comparison with 3. The compound 3 showed an increase in the values of π, Rm and Vm with respect to 6. These data indicate a high degree of lipophilicity and a low steric impediment for compound 6 in comparison with 3.
AB - Two danazol derivatives were synthesized and characterized by spectral analyses. In order to characterize the structural and chemical requirements of danazol derivatives, several parameters such as logP, π, Rm and Vm were evaluated. The results showed an increase in the values of logP for the compound 6 in comparison with 3. The compound 3 showed an increase in the values of π, Rm and Vm with respect to 6. These data indicate a high degree of lipophilicity and a low steric impediment for compound 6 in comparison with 3.
KW - Danazol derivatives
KW - Lipophilicity
KW - Steric impediment
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=79953111419&partnerID=8YFLogxK
U2 - 10.1155/2010/853298
DO - 10.1155/2010/853298
M3 - Artículo
SN - 0973-4945
VL - 7
SP - S191-S196
JO - E-Journal of Chemistry
JF - E-Journal of Chemistry
IS - SUPPL. 1
ER -