Sustainable Process for Sparteine Sulfate Preparation

Ignacio Regla, Manuel López-Ortiz, Otoniel Jiménez, Simón Hernández-Ortega, Astrid Ramírez-Betancourt, Kalina Bermúdez-Torres

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)

Resumen

(-)-Sparteine sulfate is a stable salt of the quinolizidine chiral diamine alkaloid (-)-sparteine. This compound, in addition to presenting various biological activities, has successfully been used as a ligand and organocatalyst in enantioselective lithiation reactions in asymmetric synthesis. (-)-Sparteine free base deteriorates gradually, even in refrigeration, but its stable salt, (-)-sparteine sulfate, offers advantages in handling and storage. To the best of our knowledge, no process exists in the literature for obtaining (-)-sparteine sulfate from the species of the plant genus Lupinus. In this work, we present an efficient and sustainable process to obtain (-)-sparteine sulfate and free base (-)-sparteine from leaves and stems of Lupinus montanus.

Idioma originalInglés
Páginas (desde-hasta)2567-2570
Número de páginas4
PublicaciónOrganic Process Research and Development
Volumen23
N.º11
DOI
EstadoPublicada - 15 nov. 2019

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