Supramolecular complex formation, a possible antigenotoxic mechanism of glucomannan against aflatoxin B1

Eduardo Madrigal-Santillán, Eduardo Madrigal-Bujaidar, Alicia Reyes-Arellano, José Antonio Morales-González, Isela Álvarez-González, Manuel Sánchez-Gutiérrez, Jeannett A. Izquierdo-Vega, Claudia C. Calzada-Mendoza, Liliana Anguiano-Robledo, Ángel Morales-González

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Glucomannan is a highly branched polysaccharide with glycosidic linkages, constituted of mannoses and glucoses. In recent years, its usefulness due to its immunological, antioxidant and antimutagenic activity has been recognized. The aim of the study was to determine the antigenotoxic ability of glucomannan extracted from Candida utilis orally administered (100–700 mg/kg) to mice, which subsequently received 1 mg/kg aflatoxin B1. Hepatocytes obtained from these animals 4–16 h post administration were examined by means of the comet assay. The antigenotoxic effect was found to be higher than that observed in previous studies with α-mannan and β-D-glucan isolated from Saccharomyces cerevisiae., In order to explore the possibility of formation of a supramolecular complex between glucomannan and aflatoxin B1, both compounds were co-crystallized, their melting points determined, and the complex analyzed through ultraviolet spectroscopy. The spectroscopy data suggest that the protective effect of glucomannan is related to the formation of a supramolecular complex between the two compounds.

Idioma originalInglés
Páginas (desde-hasta)369-388
Número de páginas20
PublicaciónToxicological and Environmental Chemistry
Volumen101
N.º7-8
DOI
EstadoPublicada - 14 sep. 2019

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