TY - JOUR
T1 - 1H NMR metabolomic signatures related to giant cell tumor of the bone
AU - Martínez-López, Francisco Javier
AU - Bañuelos-Hernández, Angel E.
AU - Becerra-Martínez, Elvia
AU - Santini-Araujo, Eduardo
AU - Amaya-Zepeda, Ruben A.
AU - Pérez-Hernández, Elizabeth
AU - Pérez-Hernández, Nury
N1 - Publisher Copyright:
© 2017 The Royal Society of Chemistry.
PY - 2017
Y1 - 2017
N2 - Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the 1H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications.
AB - Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the 1H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications.
UR - http://www.scopus.com/inward/record.url?scp=85030237200&partnerID=8YFLogxK
U2 - 10.1039/c7ra07138h
DO - 10.1039/c7ra07138h
M3 - Artículo
SN - 2046-2069
VL - 7
SP - 45385
EP - 45392
JO - RSC Advances
JF - RSC Advances
IS - 72
ER -