TY - JOUR
T1 - Structural consequences of the polymorphism Q223R in the human leptin receptor
T2 - A molecular dynamics study
AU - Carrillo-Vázquez, Jonathan P.
AU - Chimal-Vega, Brenda
AU - Zamora-López, Beatriz
AU - Marchat, Laurence A.
AU - Benítez-Cardoza, Claudia G.
AU - Reyes-López, César A.S.
AU - Zamorano-Carrillo, Absalom
PY - 2013/9/23
Y1 - 2013/9/23
N2 - Leptin Receptor (LEPR) is a component of a signaling pathway related to appetite and energy expenditure. Single Nucleotide Polymorphisms (SNP) of Leptin receptor gene (lepr) have been proposed as possible modulator of adipose tissue and body weight. The main phenomenological consequence reported of these SNPs is the modulation of the LEP-LEPR interaction promoting the weight gain. Particularly, Q223R polymorphism has been associated with human obesity in some populations. In this work, we analyze the structural effects of Q223R substitution in a model of the extracellular region of LEPR comparing the stability between LEPR-Q and its Q223R variant (rs1137101) by Molecular Dynamics (MD) simulations. These results showed different behavior between both molecules after one nanosecond (ns) of simulation and significant differences in the secondary structure content were evidenced.
AB - Leptin Receptor (LEPR) is a component of a signaling pathway related to appetite and energy expenditure. Single Nucleotide Polymorphisms (SNP) of Leptin receptor gene (lepr) have been proposed as possible modulator of adipose tissue and body weight. The main phenomenological consequence reported of these SNPs is the modulation of the LEP-LEPR interaction promoting the weight gain. Particularly, Q223R polymorphism has been associated with human obesity in some populations. In this work, we analyze the structural effects of Q223R substitution in a model of the extracellular region of LEPR comparing the stability between LEPR-Q and its Q223R variant (rs1137101) by Molecular Dynamics (MD) simulations. These results showed different behavior between both molecules after one nanosecond (ns) of simulation and significant differences in the secondary structure content were evidenced.
KW - Homology modeling
KW - Leptin Receptor
KW - Molecular dynamics
KW - Obesity
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84887308364&partnerID=8YFLogxK
U2 - 10.3844/ajabssp.2013.239.248
DO - 10.3844/ajabssp.2013.239.248
M3 - Artículo
SN - 1557-4989
VL - 8
SP - 239
EP - 248
JO - American Journal of Agricultural and Biological Science
JF - American Journal of Agricultural and Biological Science
IS - 3
ER -