TY - JOUR
T1 - Stress proteins in the pathogenesis of spondyloarthritis
AU - Romero-López, José Pablo
AU - Domínguez-López, María Lilia
AU - Burgos-Vargas, Rubén
AU - García-Latorre, Ethel
N1 - Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/4/10
Y1 - 2019/4/10
N2 - Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the molecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease.
AB - Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the molecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease.
KW - Cell stress
KW - HLA-B27
KW - HSP60
KW - Heat-shock proteins
KW - Spondyloarthritis
UR - http://www.scopus.com/inward/record.url?scp=85047957785&partnerID=8YFLogxK
U2 - 10.1007/s00296-018-4070-9
DO - 10.1007/s00296-018-4070-9
M3 - Artículo de revisión
C2 - 29855675
SN - 0172-8172
VL - 39
SP - 595
EP - 604
JO - Rheumatology International
JF - Rheumatology International
IS - 4
ER -