Strain differences of dopamine receptor levels and dopamine related behaviors in rats

Sergio Zamudio, Tomás Fregoso, Abraham Miranda, Fidel De La Cruz, Gonzalo Flores

Resultado de la investigación: Contribución a una revistaArtículo

27 Citas (Scopus)

Resumen

Here we have investigated whether differences in levels of dopamine D1-like, D2-like receptors, dopamine D3 receptors, and dopamine transporter could be related to behaviors such as immobility response and locomotion between Wistar rats and Sprague-Dawley rats. The levels of the dopamine receptors and transporter were measured by autoradiographic study at the level of basal ganglia and the limbic subregion. The behavioral study was done by open-field and immobility response tests. The Wistar rats exhibited a higher level of D1 receptor binding in the basal ganglia subregions than Sprague-Dawley rats. The Wistar rats have higher levels of dopamine D2 receptor binding and dopamine transporter binding in the dorsolateral part of the caudate-putamen. In addition, the dopamine transporter binding were also higher in the Wistar rats than in Sprague-Dawley rats in the ventral part of the caudate-putamen and nucleus accumbens core. However, there were no differences in the level of D3 receptor binding in the limbic or basal ganglia subregions between these two strains. In Wistar rats, the duration of the immobility responses was longer and with less locomotor activity after these immobility responses compared with Sprague-Dawley rats. These data suggest that the differences in dopamine receptors in these two rat strains may in part relate to the behavioral differences reported in these two strains. © 2005 Elsevier Inc. All rights reserved.
Idioma originalInglés estadounidense
Páginas (desde-hasta)339-347
Número de páginas304
PublicaciónBrain Research Bulletin
DOI
EstadoPublicada - 30 abr 2005

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