Stage determination of breast cancer biopsy using raman spectroscopy and multivariate analysis

J. L. González-Solís, B. I. Aguiñaga-Serrano, J. C. Martínez-Espinosa, A. Oceguera-Villanueva

Producción científica: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

8 Citas (Scopus)

Resumen

The use of Raman spectroscopy to analyze biopsy biochemistry and hence distinguish between the breast cancer stages was investigated. The biopsy samples were obtained from 13 patients who were clinically diagnosed with breast cancer. A preliminary diagnosis of some breast cancer patient was realized by pathologist of the Cancer Institute. The biopsies were put under the microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with a NIR 830 nm laser. It is shown that the breast cancer stages of biopsies can be discriminated when the Principal Components Analysis (PCA) is applied to their Raman spectra. Ratios of some band intensities were analyzed and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be an excellent technique for stage determination of breast cancer.

Idioma originalInglés
Título de la publicación alojadaAdvances in Laserology - Selected Papers of Laser Florence 2010
Subtítulo de la publicación alojadaThe 50th Birthday of Laser Medicine World
Páginas33-40
Número de páginas8
DOI
EstadoPublicada - 2011
Publicado de forma externa
EventoAnnual Congress of the International Academy Laser Medicine and Surgery, Laser Florence 2010 - Florence, Italia
Duración: 5 nov. 20106 nov. 2010

Serie de la publicación

NombreAIP Conference Proceedings
Volumen1364
ISSN (versión impresa)0094-243X
ISSN (versión digital)1551-7616

Conferencia

ConferenciaAnnual Congress of the International Academy Laser Medicine and Surgery, Laser Florence 2010
País/TerritorioItalia
CiudadFlorence
Período5/11/106/11/10

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