TY - JOUR
T1 - Silica from rice husks employed as drug delivery for folic acid
AU - Salazar Hernández, Mercedes
AU - Salazar Hernández, Carmen
AU - Gutiérrez Fuentes, Alfredo
AU - Elorza, Enrique
AU - Carrera-Rodríguez, Marcelino
AU - Puy Alquiza, María J.
N1 - Funding Information:
Acknowledgments The authors wish to acknowledge the financial support of the Instituto Politécnico Nacional through grant SIP-20130874. Also, acknowledge to Rocío Lona Ramos for her technical support in this work.
PY - 2014/9
Y1 - 2014/9
N2 - Silica was obtained from rice husk, this type of silica is also known as SiO2-rice, was investigated as drug delivery for the folic acid. The SiO2-rice was obtained from calcinations at 600 °C and its textural properties were compared with mesoporous silica (MS). The maximum folic acid adsorption on SiO2-rice was at the 18 % weight, while MS adsorbs 19 % weight. An important pH effect on the drug released was observed; both silicas released around 35 % of acid folic at pH 7, while at pH 3 only 3 % of the drug was released. Differential Thermal Analyzer analysis suggests that the folic acid was not crystallized into the porous of the silica; therefore, it is possible that the drug was trapped within the complex network of pores preventing their full release. However, the drug released for 400 μg of folic acid, a commercial dose, indicated that until 93 % of drug could be released for the silicas at pH of 5.5; a minor desorption was observed by commercial tablet.
AB - Silica was obtained from rice husk, this type of silica is also known as SiO2-rice, was investigated as drug delivery for the folic acid. The SiO2-rice was obtained from calcinations at 600 °C and its textural properties were compared with mesoporous silica (MS). The maximum folic acid adsorption on SiO2-rice was at the 18 % weight, while MS adsorbs 19 % weight. An important pH effect on the drug released was observed; both silicas released around 35 % of acid folic at pH 7, while at pH 3 only 3 % of the drug was released. Differential Thermal Analyzer analysis suggests that the folic acid was not crystallized into the porous of the silica; therefore, it is possible that the drug was trapped within the complex network of pores preventing their full release. However, the drug released for 400 μg of folic acid, a commercial dose, indicated that until 93 % of drug could be released for the silicas at pH of 5.5; a minor desorption was observed by commercial tablet.
KW - Drug delivery
KW - Folic acid
KW - Mesoporous silica
UR - http://www.scopus.com/inward/record.url?scp=84906053684&partnerID=8YFLogxK
U2 - 10.1007/s10971-014-3378-5
DO - 10.1007/s10971-014-3378-5
M3 - Artículo
SN - 0928-0707
VL - 71
SP - 514
EP - 521
JO - Journal of Sol-Gel Science and Technology
JF - Journal of Sol-Gel Science and Technology
IS - 3
ER -