TY - JOUR
T1 - Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin
AU - Soria-Castro, Rodolfo
AU - Meneses-Preza, Yatsiri G.
AU - Rodríguez-López, Gloria M.
AU - Romero-Ramírez, Sandra
AU - Sosa-Hernández, Víctor A.
AU - Cervantes-Díaz, Rodrigo
AU - Pérez-Fragoso, Alfredo
AU - Torres-Ruíz, José J.
AU - Gómez-Martín, Diana
AU - Campillo-Navarro, Marcia
AU - Álvarez-Jiménez, Violeta D.
AU - Pérez-Tapia, Sonia M.
AU - Chávez-Blanco, Alma D.
AU - Estrada-Parra, Sergio
AU - Maravillas-Montero, José L.
AU - Chacón-Salinas, Rommel
N1 - Publisher Copyright:
© 2021 Society for Leukocyte Biology
PY - 2021/9
Y1 - 2021/9
N2 - The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection ranging from protection to tissue damage and all occur in the development of acute respiratory distress syndrome (ARDS). ARDS patients display elevated levels of inflammatory cytokines and innate immune cells, and T and B cell lymphocytes have been implicated in this dysregulated immune response. Mast cells are abundant resident cells of the respiratory tract and are able to release different inflammatory mediators rapidly following stimulation. Recently, mast cells have been associated with tissue damage during viral infections, but their role in SARS-CoV-2 infection remains unclear. In this study, we examined the profile of mast cell activation markers in the serum of COVID-19 patients. We noticed that SARS-CoV-2-infected patients showed increased carboxypeptidase A3 (CPA3) and decreased serotonin levels in their serum when compared with symptomatic SARS-CoV-2-negative patients. CPA3 levels correlated with C-reactive protein, the number of circulating neutrophils, and quick SOFA. CPA3 in serum was a good biomarker for identifying severe COVID-19 patients, whereas serotonin was a good predictor of SARS-CoV-2 infection. In summary, our results show that serum CPA3 and serotonin levels are relevant biomarkers during SARS-CoV-2 infection. This suggests that mast cells and basophils are relevant players in the inflammatory response in COVID-19 and may represent targets for therapeutic intervention.
AB - The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection ranging from protection to tissue damage and all occur in the development of acute respiratory distress syndrome (ARDS). ARDS patients display elevated levels of inflammatory cytokines and innate immune cells, and T and B cell lymphocytes have been implicated in this dysregulated immune response. Mast cells are abundant resident cells of the respiratory tract and are able to release different inflammatory mediators rapidly following stimulation. Recently, mast cells have been associated with tissue damage during viral infections, but their role in SARS-CoV-2 infection remains unclear. In this study, we examined the profile of mast cell activation markers in the serum of COVID-19 patients. We noticed that SARS-CoV-2-infected patients showed increased carboxypeptidase A3 (CPA3) and decreased serotonin levels in their serum when compared with symptomatic SARS-CoV-2-negative patients. CPA3 levels correlated with C-reactive protein, the number of circulating neutrophils, and quick SOFA. CPA3 in serum was a good biomarker for identifying severe COVID-19 patients, whereas serotonin was a good predictor of SARS-CoV-2 infection. In summary, our results show that serum CPA3 and serotonin levels are relevant biomarkers during SARS-CoV-2 infection. This suggests that mast cells and basophils are relevant players in the inflammatory response in COVID-19 and may represent targets for therapeutic intervention.
KW - COVID-19
KW - Mast cell
KW - SARS-CoV-2
KW - carboxypeptidase A3
KW - serotonin
UR - http://www.scopus.com/inward/record.url?scp=85107027759&partnerID=8YFLogxK
U2 - 10.1002/JLB.4HI0221-087R
DO - 10.1002/JLB.4HI0221-087R
M3 - Artículo
C2 - 34057753
AN - SCOPUS:85107027759
SN - 0741-5400
VL - 110
SP - 425
EP - 431
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 3
ER -