TY - JOUR
T1 - Regulation of intestinal morphology and GALT by pituitary hormones in the rat
AU - Cárdenas-Jaramillo, Luz María
AU - Quintanar-Stephano, Andrés
AU - Jarillo-Luna, Rosa Adriana
AU - Rivera-Aguilar, Víctor
AU - Oliver-Aguillón, Gabriela
AU - Campos-Rodríguez, Rafael
AU - Kovacs, Kalman
AU - Berczi, Istvan
PY - 2012/7
Y1 - 2012/7
N2 - Here, the effects of neurointermediate (NIL), anterior (AL), and total hypophysectomy (HYPOX) on ileal mucosa cells and gut-associated lymphoid tissue (GALT) are reported. Compared with the sham-operated (SHAM) rats, the villi height and goblet cells numbers were significantly decreased in all groups. Lamina propria area decreased in AL and HYPOX, but not in NIL animals. CD8+ but not CD4+ lymphocytes decreased in the HYPOX and NIL groups. Paneth cells did not change, while IgA cells, IgM cells, and secretory IgA were significantly decreased in all groups. NIL but not AL animals lost significant numbers of IgA cells and secretory IgA. In summary, pituitary hormones exert lobe-specific regulatory effects on the gut and on GALT.
AB - Here, the effects of neurointermediate (NIL), anterior (AL), and total hypophysectomy (HYPOX) on ileal mucosa cells and gut-associated lymphoid tissue (GALT) are reported. Compared with the sham-operated (SHAM) rats, the villi height and goblet cells numbers were significantly decreased in all groups. Lamina propria area decreased in AL and HYPOX, but not in NIL animals. CD8+ but not CD4+ lymphocytes decreased in the HYPOX and NIL groups. Paneth cells did not change, while IgA cells, IgM cells, and secretory IgA were significantly decreased in all groups. NIL but not AL animals lost significant numbers of IgA cells and secretory IgA. In summary, pituitary hormones exert lobe-specific regulatory effects on the gut and on GALT.
KW - Anterior and neurointermediate pituitary lobectomy
KW - Gut associated lymphoid tissue
KW - Gut morphology
KW - Hypophysectomy
KW - Pituitary hormones
UR - http://www.scopus.com/inward/record.url?scp=84864085588&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2012.06648.x
DO - 10.1111/j.1749-6632.2012.06648.x
M3 - Artículo
AN - SCOPUS:84864085588
SN - 0077-8923
VL - 1261
SP - 72
EP - 78
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -