Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

Juan Castelán-Vega; Laura Corvette; Lev Sirota; Juan Arciniega

doi:10.1128/CVI.00267-10

Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

Juan Castelán-Vega, Laura Corvette, Lev Sirota, Juan Arciniega

Escuela Nacional de Ciencias Biológicas (ENCB)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

15 Citas (Scopus)

Resumen

We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge.

Idioma original	Inglés
Páginas (desde-hasta)	349-351
Número de páginas	3
Publicación	Clinical and Vaccine Immunology
Volumen	18
N.º	2
DOI	https://doi.org/10.1128/CVI.00267-10
Estado	Publicada - feb. 2011

ODS de las Naciones Unidas

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abstract = "We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge.",

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AU - Sirota, Lev

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Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

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