TY - JOUR
T1 - Reconstructing Native American population history
AU - Reich, David
AU - Patterson, Nick
AU - Campbell, Desmond
AU - Tandon, Arti
AU - Mazieres, Stéphane
AU - Ray, Nicolas
AU - Parra, Maria V.
AU - Rojas, Winston
AU - Duque, Constanza
AU - Mesa, Natalia
AU - García, Luis F.
AU - Triana, Omar
AU - Blair, Silvia
AU - Maestre, Amanda
AU - Dib, Juan C.
AU - Bravi, Claudio M.
AU - Bailliet, Graciela
AU - Corach, Daniel
AU - Hünemeier, Tábita
AU - Bortolini, Maria Cátira
AU - Salzano, Francisco M.
AU - Petzl-Erler, María Luiza
AU - Acuña-Alonzo, Victor
AU - Aguilar-Salinas, Carlos
AU - Canizales-Quinteros, Samuel
AU - Tusié-Luna, Teresa
AU - Riba, Laura
AU - Rodríguez-Cruz, Maricela
AU - Lopez-Alarcón, Mardia
AU - Coral-Vazquez, Ramón
AU - Canto-Cetina, Thelma
AU - Silva-Zolezzi, Irma
AU - Fernandez-Lopez, Juan Carlos
AU - Contreras, Alejandra V.
AU - Jimenez-Sanchez, Gerardo
AU - Gómez-Vázquez, Maria José
AU - Molina, Julio
AU - Carracedo, Ángel
AU - Salas, Antonio
AU - Gallo, Carla
AU - Poletti, Giovanni
AU - Witonsky, David B.
AU - Alkorta-Aranburu, Gorka
AU - Sukernik, Rem I.
AU - Osipova, Ludmila
AU - Fedorova, Sardana A.
AU - Vasquez, René
AU - Villena, Mercedes
AU - Moreau, Claudia
AU - Barrantes, Ramiro
AU - Pauls, David
AU - Excoffier, Laurent
AU - Bedoya, Gabriel
AU - Rothhammer, Francisco
AU - Dugoujon, Jean Michel
AU - Larrouy, Georges
AU - Klitz, William
AU - Labuda, Damian
AU - Kidd, Judith
AU - Kidd, Kenneth
AU - Di Rienzo, Anna
AU - Freimer, Nelson B.
AU - Price, Alkes L.
AU - Ruiz-Linares, Andrés
N1 - Funding Information:
AcknowledgementsWethankthe volunteers who providedthesamples that madethis study possible. We thank E. D. Ruiz for assistance in the collection involving the Mixtec, ZapotecandMixe;andP.Herrerafor assistance inthe collectioninvolvingthe Quechua; A. Carnevale, M. Crawford, M. Metspalu, F. C. Nielsen, X. Soberon, R. Villems and E. Willerslev for facilitating sharing of data from Mexican, Siberian and Arctic populations; C. Stevens and A. Crenshaw for assistance with genotyping; and P. Bellwood, D. Bolnick, K. Bryc, J. Diamond, T. Dillehay, R. Gonzalez-José, M. Hammer, J. Hill, B. Kemp, S. LeBlanc, D. Meltzer, P. Moorjani, A. Moreno-Estrada, B. Pakendorf, J. Pickrell, M. Ruhlen, D. G. Smith, M. Stoneking, N. Tuross and A. Williams for critiques and discussions. Support was provided by National Institutes of Health grants NS043538 (A.R.-L.), NS037484 and MH075007 (N.B.F.), GM079558 (A.D.), GM079558-S1 (A.D.), GM057672 (K.K.K. and J.R.K.), and HG006399 (D.R., N.P. & A.L.P); by a Biotechnology and Biological Sciences Research Council grant BB/ 1021213/1; by a National Science Foundation HOMINID grant BCS-1032255 (D.R. and N.P.); by a Canadian Institutes of Health Research grant (D.L.); by a Universidad de Antioquia CODI grant (G.B.); by a Fondo de Investigación Sanitaria grant PS 09/2368 (A.C.); by a Ministerio de Ciencia e Innovacion grant SAF2011-26983 (A.S.); by a Wenner-Gren Foundation grant ICRG-65 (A.D. and R.S.); by Russian Foundation for Basic Research grants 06-04-048182 (R.S.) and 02-06-80524a (L.O.); by a Siberian Branch Russian Academy of Sciences field grant (L.O.); by a Centre National de la Recherche Scientifique Programme Interdisciplinaire de Recherche Amazonie grant (J.-M.D.); and by startup funds from Harvard Medical School (D.R.) and the Harvard School of Public Health (A.L.P.).
PY - 2012/8/16
Y1 - 2012/8/16
N2 - The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means of a single migration or multiple streams of migration from Siberia. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call First American. However, speakers of Eskimog-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America.
AB - The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means of a single migration or multiple streams of migration from Siberia. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call First American. However, speakers of Eskimog-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America.
UR - http://www.scopus.com/inward/record.url?scp=84865120805&partnerID=8YFLogxK
U2 - 10.1038/nature11258
DO - 10.1038/nature11258
M3 - Artículo de revisión
C2 - 22801491
SN - 0028-0836
VL - 488
SP - 370
EP - 374
JO - Nature
JF - Nature
IS - 7411
ER -