Pyrrolizidine Alkaloids

Joaquín Tamariz; Eleuterio Burgueño-Tapia; Miguel A. Vázquez; Francisco Delgado

doi:10.1016/bs.alkal.2018.03.001

Pyrrolizidine Alkaloids

Joaquín Tamariz, Eleuterio Burgueño-Tapia, Miguel A. Vázquez, Francisco Delgado

Escuela Nacional de Ciencias Biológicas (ENCB)

Producción científica: Capítulo del libro/informe/acta de congreso › Capítulo › revisión exhaustiva

47 Citas (Scopus)

Resumen

Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources. The interest of the scientific community in these compounds owes itself to their high toxicity and biological activity, as well as to the challenge of synthesizing their pyrrolizidine scaffold. This review encompasses a wide range of topics found in the literature from 1995 to date, including the occurrence, biosynthesis, toxicity (hepatotoxicity, genotoxicity, and tumorigenicity), biological activity, and pharmacological properties (glycosidase inhibitory activity) of these secondary metabolites. Particular attention is given to the chemistry of PAs, addressing general strategies for formal and total syntheses via amino-based substrates, pyrroles, and pyrrolidine-based derivatives.

Idioma original	Inglés
Título de la publicación alojada	Alkaloids
Subtítulo de la publicación alojada	Chemistry and Biology
Editores	Hans-Joachim Knölker
Editorial	Academic Press Inc.
Páginas	1-314
Número de páginas	314
ISBN (versión impresa)	9780128157909
DOI	https://doi.org/10.1016/bs.alkal.2018.03.001
Estado	Publicada - 1 ene. 2018

Serie de la publicación

Nombre	Alkaloids: Chemistry and Biology
Volumen	80
ISSN (versión impresa)	1099-4831

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abstract = "Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources. The interest of the scientific community in these compounds owes itself to their high toxicity and biological activity, as well as to the challenge of synthesizing their pyrrolizidine scaffold. This review encompasses a wide range of topics found in the literature from 1995 to date, including the occurrence, biosynthesis, toxicity (hepatotoxicity, genotoxicity, and tumorigenicity), biological activity, and pharmacological properties (glycosidase inhibitory activity) of these secondary metabolites. Particular attention is given to the chemistry of PAs, addressing general strategies for formal and total syntheses via amino-based substrates, pyrroles, and pyrrolidine-based derivatives.",

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AU - Burgueño-Tapia, Eleuterio

AU - Vázquez, Miguel A.

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KW - Glycosidase inhibition

KW - Hepatotoxicity

KW - Natural occurrence

KW - Necine bases

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KW - Pyrrolizidine synthesis

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Pyrrolizidine Alkaloids

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