Pyrrolizidine Alkaloids

    Resultado de la investigación: Capítulo del libro/informe/acta de congresoCapítulorevisión exhaustiva

    22 Citas (Scopus)

    Resumen

    Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources. The interest of the scientific community in these compounds owes itself to their high toxicity and biological activity, as well as to the challenge of synthesizing their pyrrolizidine scaffold. This review encompasses a wide range of topics found in the literature from 1995 to date, including the occurrence, biosynthesis, toxicity (hepatotoxicity, genotoxicity, and tumorigenicity), biological activity, and pharmacological properties (glycosidase inhibitory activity) of these secondary metabolites. Particular attention is given to the chemistry of PAs, addressing general strategies for formal and total syntheses via amino-based substrates, pyrroles, and pyrrolidine-based derivatives.

    Idioma originalInglés
    Título de la publicación alojadaAlkaloids
    Subtítulo de la publicación alojadaChemistry and Biology
    EditoresHans-Joachim Knölker
    EditorialAcademic Press Inc.
    Páginas1-314
    Número de páginas314
    ISBN (versión impresa)9780128157909
    DOI
    EstadoPublicada - 1 ene 2018

    Serie de la publicación

    NombreAlkaloids: Chemistry and Biology
    Volumen80
    ISSN (versión impresa)1099-4831

    Huella

    Profundice en los temas de investigación de 'Pyrrolizidine Alkaloids'. En conjunto forman una huella única.

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