TY - JOUR
T1 - PTPN22 gene functional polymorphism (rs2476601) in older adults with frailty syndrome
AU - Rabaneda-Bueno, Rubén
AU - Torres-Carrillo, Norma
AU - Ávila-Funes, José Alberto
AU - Gutiérrez-Robledo, Luis Miguel
AU - Pérez-Suárez, Thalía Gabriela
AU - Acosta, José Luis
AU - Torres-Castro, Sara
AU - Fletes-Rayas, Ana Lilia
AU - Gutierrez-Hurtado, Itzae
AU - Sandoval-Pinto, Elena
AU - Cremades, Rosa
AU - Torres-Carrillo, Nora Magdalena
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.
PY - 2021/2
Y1 - 2021/2
N2 - The frailty syndrome is a common clinical marker of vulnerability in older adults conducive to an overall decline in inflammatory stress responsiveness; yet little is known about the genetic risk factors for frailty in elderly. Our aim was to investigate the association between the rs2476601 polymorphism in PTPN22 gene and susceptibility to frailty in Mexican older adults. Data included 630 subjects 70 and older from The Coyoacán cohort, classified as frail, pre-frail, and non-frail following Fried’s criteria. Sociodemographic and clinical characteristics were compared between groups at baseline and after a multivariate analysis. The rs2476601 polymorphism was genotyped by TaqMan genotyping assay using real-time PCR and genotype frequencies were determined for each frailty phenotype in all participants and subsets by age range. Genetic association was examined using stratified and interaction analyses adjusting for age, sex and variables selected in the multivariate analysis. Disability for day-life activities, depression and cognitive impairment were associated with the risk of pre-frailty and frailty at baseline and after adjustment. Carrying the T allele increased significantly the risk of frailty in patients 76 and older (OR 5.64, 95% CI 4.112–7.165) and decreased the risk of pre-frailty under no clinical signs of depression (OR 0.53; 95% CI 0.17–1.71). The PTPN22 polymorphism, rs2476601, could be a genetic risk factor for frailty as subject to quality of life. This is the first study analyzing such relationship in Mexican older adults. Confirming these findings requires additional association studies on wider age ranges in populations of older adults with frailty syndrome.
AB - The frailty syndrome is a common clinical marker of vulnerability in older adults conducive to an overall decline in inflammatory stress responsiveness; yet little is known about the genetic risk factors for frailty in elderly. Our aim was to investigate the association between the rs2476601 polymorphism in PTPN22 gene and susceptibility to frailty in Mexican older adults. Data included 630 subjects 70 and older from The Coyoacán cohort, classified as frail, pre-frail, and non-frail following Fried’s criteria. Sociodemographic and clinical characteristics were compared between groups at baseline and after a multivariate analysis. The rs2476601 polymorphism was genotyped by TaqMan genotyping assay using real-time PCR and genotype frequencies were determined for each frailty phenotype in all participants and subsets by age range. Genetic association was examined using stratified and interaction analyses adjusting for age, sex and variables selected in the multivariate analysis. Disability for day-life activities, depression and cognitive impairment were associated with the risk of pre-frailty and frailty at baseline and after adjustment. Carrying the T allele increased significantly the risk of frailty in patients 76 and older (OR 5.64, 95% CI 4.112–7.165) and decreased the risk of pre-frailty under no clinical signs of depression (OR 0.53; 95% CI 0.17–1.71). The PTPN22 polymorphism, rs2476601, could be a genetic risk factor for frailty as subject to quality of life. This is the first study analyzing such relationship in Mexican older adults. Confirming these findings requires additional association studies on wider age ranges in populations of older adults with frailty syndrome.
KW - Frailty syndrome
KW - Lymphoid tyrosine phosphatase locus (LYP/PTPN22)
KW - Multivariate analysis
KW - Older adults
KW - PTPN22 gene polymorphism
KW - SNP rs2476601
UR - http://www.scopus.com/inward/record.url?scp=85101264748&partnerID=8YFLogxK
U2 - 10.1007/s11033-021-06212-4
DO - 10.1007/s11033-021-06212-4
M3 - Artículo
C2 - 33611779
AN - SCOPUS:85101264748
SN - 0301-4851
VL - 48
SP - 1193
EP - 1204
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 2
ER -