TY - JOUR
T1 - Pharmacokinetics of oral ketorolac in the rat
AU - Granados-Soto, V.
AU - Flores-Murrieta, F. J.
PY - 1995
Y1 - 1995
N2 - The pharmacokinetics of ketorolac, a potent analgesic agent used for relief of moderate to severe pain, has been studied in rats who received oral doses of 1, 3.2 or 5.6 mg/kg of ketorolac tromethamine. Blood samples were obtained at selected times during 24 h after medication, and ketorolac concentrations were determined by high performance liquid chromatography. After administration of ketorolac, blood concentrations increased rapidly reaching a dose-dependent maximal concentration in about 20 min. Then, concentrations decayed with a half-life of about 6 h. A linear increase in C(max) and AUC as a function of the dose was observed, and no statistically signifcant difference was observed in AUC/dose or C(max)/dose between doses, indicating that pharmacokinetics of ketorolac is linear in the range of doses studied.
AB - The pharmacokinetics of ketorolac, a potent analgesic agent used for relief of moderate to severe pain, has been studied in rats who received oral doses of 1, 3.2 or 5.6 mg/kg of ketorolac tromethamine. Blood samples were obtained at selected times during 24 h after medication, and ketorolac concentrations were determined by high performance liquid chromatography. After administration of ketorolac, blood concentrations increased rapidly reaching a dose-dependent maximal concentration in about 20 min. Then, concentrations decayed with a half-life of about 6 h. A linear increase in C(max) and AUC as a function of the dose was observed, and no statistically signifcant difference was observed in AUC/dose or C(max)/dose between doses, indicating that pharmacokinetics of ketorolac is linear in the range of doses studied.
KW - ketorolac tromethamine
KW - pharmacokinetics
KW - rat
UR - http://www.scopus.com/inward/record.url?scp=0028850355&partnerID=8YFLogxK
M3 - Artículo
SN - 0379-0355
VL - 17
SP - 535
EP - 538
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology
IS - 8
ER -