Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs

Esaú Floriano-Sánchez, Cleva Villanueva, Omar Noel Medina-Campos, Diana Rocha, Dolores Javier Sanchez-González, Noemí Cardenas-Rodríguez, José Pedraza-Chaverrí

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

125 Citas (Scopus)

Resumen

The antioxidant nordihydroguaiaretic acid (NDGA) has recently become well known as a putative anticancer drug. In this paper, it was evaluated the in vitro peroxynitrite (ONOO-), singlet oxygen (1O2), hydroxyl radical (OH), hydrogen peroxide (H2O2), superoxide anion (O2•- and hypochlorous acid (HOCl) scavenging capacity of NDGA. It was found that NDGA scavenges: (a) ONOO- (IC50 = 4 ± 0.94 μM) as efficiently as uric acid; (b) 1O2 (IC50 = 151 ± 20 μM) more efficiently than dimethyl thiourea, lipoic acid, N-acetyl-cysteine and glutathione; (c) OH (IC50 = 0.15 ± 0.02 μM) more efficiently than dimethyl thiourea, uric acid, trolox, dimethyl sulfoxide and mannitol, (d) O2•- (IC50 = 15 ± 1 μM) more efficiently than N-acetyl-cysteine, glutathione, tempol and deferoxamine and (e) HOCl (IC50 = 622 ± 42 μ M) as efficiently as lipoic acid and N-acetyl-cysteine. NDGA was unable to scavenge H2 O2. In an in vivo study in rats, NDGA was able to prevent ozone-induced tyrosine nitration in lungs. It is concluded that NDGA is a potent in vitro scavenger of ONOO-, 1O2, OH, O2•- and HOCl and is able to prevent lung tyrosine nitration in vivo.

Idioma originalInglés
Páginas (desde-hasta)523-533
Número de páginas11
PublicaciónFree Radical Research
Volumen40
N.º5
DOI
EstadoPublicada - may. 2006

Huella

Profundice en los temas de investigación de 'Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs'. En conjunto forman una huella única.

Citar esto