TY - JOUR
T1 - Non-Invasive biomarkers for duchenne muscular dystrophy and carrier detection
AU - Anaya-Segura, Mónica Alejandra
AU - García-Martínez, Froylan Arturo
AU - Montes-Almanza, Luis Ángel
AU - Díaz, Benjamín Gómez
AU - Ávila-Ramírez, Guillermina
AU - Alvarez-Maya, Ikuri
AU - Coral-Vázquez, Ramón Mauricio
AU - Mondragón-Terán, Paul
AU - Escobar-Cedillo, Rosa Elena
AU - García-Calderón, Noemí
AU - Vázquez-Cardenas, Norma Alejandra
AU - García, Silvia
AU - López-Hernández, Luz Berenice
N1 - Publisher Copyright:
© 2015 by the authors.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Non-invasive biological indicators of the absence/presence or progress of the disease that could be used to support diagnosis and to evaluate the effectiveness of treatment are of utmost importance in Duchenne Muscular Dystrophy (DMD). This neuromuscular disorder affects male children, causing weakness and disability, whereas female relatives are at risk of being carriers of the disease. A biomarker with both high sensitivity and specificity for accurate prediction is preferred. Until now creatine kinase (CK) levels have been used for DMD diagnosis but these fail to assess disease progression. Herein we examined the potential applicability of serum levels of matrix metalloproteinase 9 (MMP-9) and matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 1 (TIMP-1), myostatin (GDF-8) and follistatin (FSTN) as non-invasive biomarkers to distinguish between DMD steroid naïve patients and healthy controls of similar age and also for carrier detection.
AB - Non-invasive biological indicators of the absence/presence or progress of the disease that could be used to support diagnosis and to evaluate the effectiveness of treatment are of utmost importance in Duchenne Muscular Dystrophy (DMD). This neuromuscular disorder affects male children, causing weakness and disability, whereas female relatives are at risk of being carriers of the disease. A biomarker with both high sensitivity and specificity for accurate prediction is preferred. Until now creatine kinase (CK) levels have been used for DMD diagnosis but these fail to assess disease progression. Herein we examined the potential applicability of serum levels of matrix metalloproteinase 9 (MMP-9) and matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 1 (TIMP-1), myostatin (GDF-8) and follistatin (FSTN) as non-invasive biomarkers to distinguish between DMD steroid naïve patients and healthy controls of similar age and also for carrier detection.
KW - Biomarkers
KW - Duchenne
KW - FSTN
KW - GDF-8
KW - MMP-2
KW - MMP-9
KW - Monitoring
KW - TIMP-1
UR - http://www.scopus.com/inward/record.url?scp=84938369872&partnerID=8YFLogxK
U2 - 10.3390/molecules200611154
DO - 10.3390/molecules200611154
M3 - Artículo
C2 - 26091074
SN - 1420-3049
VL - 20
SP - 11154
EP - 11172
JO - Molecules
JF - Molecules
IS - 6
ER -