TY - JOUR
T1 - Microencapsulation techniques to develop formulations of insulin for oral delivery
T2 - A review
AU - Cárdenas-Bailón, Fernando
AU - Osorio-Revilla, Guillermo
AU - Gallardo-Velázquez, Tzayhrí
N1 - Funding Information:
Financial support from Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas and CONACYT (Consejo Nacional de Ciencia y Tecnología) Mexico for the development of this study is greatly appreciated.
PY - 2013
Y1 - 2013
N2 - Oral insulin delivery represents one of the most challenging goals for pharmaceutical industry. In general, it is accepted that oral administration of insulin would be more accepted by patients and insulin would be delivered in a more physiological way than the parenteral route. From all strategies to deliverer insulin orally, microencapsulation or nanoencapsulation of insulin are the most promising approaches because these techniques protect insulin from enzymatic degradation in stomach, show a good release profile at intestine pH values, maintain biological activity during formulation and enhance intestinal permeation at certain extent. From different microencapsulation techniques, it seems that complex coacervation, multiple emulsion and internal gelation are the most appropriate techniques to encapsulate insulin due to their relative ease of preparation. Besides that, the use of organic solvents is not required and can be scaled up at low cost; however, relative oral bioavailability still needs to be improved.
AB - Oral insulin delivery represents one of the most challenging goals for pharmaceutical industry. In general, it is accepted that oral administration of insulin would be more accepted by patients and insulin would be delivered in a more physiological way than the parenteral route. From all strategies to deliverer insulin orally, microencapsulation or nanoencapsulation of insulin are the most promising approaches because these techniques protect insulin from enzymatic degradation in stomach, show a good release profile at intestine pH values, maintain biological activity during formulation and enhance intestinal permeation at certain extent. From different microencapsulation techniques, it seems that complex coacervation, multiple emulsion and internal gelation are the most appropriate techniques to encapsulate insulin due to their relative ease of preparation. Besides that, the use of organic solvents is not required and can be scaled up at low cost; however, relative oral bioavailability still needs to be improved.
KW - Insulin
KW - Insulin microencapsulation
KW - Oral delivery
KW - Peptides delivery
UR - http://www.scopus.com/inward/record.url?scp=84879556810&partnerID=8YFLogxK
U2 - 10.3109/02652048.2012.742159
DO - 10.3109/02652048.2012.742159
M3 - Artículo de revisión
C2 - 23234361
SN - 0265-2048
VL - 30
SP - 409
EP - 424
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
IS - 5
ER -