Las plantas medicinales Mexicanas como fuente de compuestos antimicobacterianos

María Adelina Jiménez Arellanes, Jorge Cornejo Garrido, Rosalba León Díaz

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

4 Citas (Scopus)

Resumen

Ca. 75 species from Mexican medicinal flora have been tested in vitro against Mycobacterium tuberculosis H37Rv. Some of these were selected based on their medicinal uses. The most active species include Phoradendron robinsonii, Larrea divericata, Amphiteryngium adstringens, Buddleja cordata, Piper sanctum, Arracacia tolucensis, Carya illinoiensis, Diospyros anisandra, and Thymus vulgaris. A number of active compounds isolated from medicinal plants by bioguided fractionation are 2-oxo-14-(3′,4′-methylenedioxyphenyl) tetradecane, 2-oxo-16-(3′,4′-methylenedioxyphenyl)-hexadecane, 5,6-dehydro-7,8-dihydromethysticin, cepharanone B, piperolactam A, suberosin, escobarine A, oleanolic acid, ursolic acid, the mixture of these two latter compounds (ursolic/oleanolic acids), and E and Z-phytols with minimal inhibitory concentration (MIC) < 25 μg/mL against M. tuberculosis H37Rv. Also some macrolactones glycolipids isolated from Ipomoea genus demonstrated important antimycobacterial activity against M. tuberculosis H37Rv (MIC < 32 μg/mL). Other secondary metabolites with antimycobacterial activity were six alkaloids, two flavonoids, two quinones and two triterpenes (MIC < 25 μg/mL).

Título traducido de la contribuciónMexican medicinal plants as a source of antimycobacterial compounds
Idioma originalFrancés
Páginas (desde-hasta)22-29
Número de páginas8
PublicaciónRevista Mexicana de Ciencias Farmaceuticas
Volumen41
N.º1
EstadoPublicada - ene 2010

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