TY - JOUR
T1 - Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression
AU - Ferreira, A.
AU - Picazo, O.
AU - Uriarte, N.
AU - Pereira, M.
AU - Fernández-Guasti, A.
N1 - Funding Information:
Authors wish to thank Mr. Facundo Moreno for skillful technical assistance. A.F. visit to Mexico City was partially supported by CONACyT and CSIC.
PY - 2000/6
Y1 - 2000/6
N2 - The action of diazepam (0.0, 1.0, and 2.0 mg/kg) and the serotonergic compounds buspirone (0.0, 2.5, and 5.0 mg/kg) and 8-OH-DPAT (0.0, 0.1, and 1.0 mg/kg) on maternal behavior and aggression were studied. An activity test was made after these treatments to control for unspecific actions due to motor impairment. Diazepam and buspirone dose-dependently inhibited the expression of maternal aggression and the active components of maternal behavior such as retrieving and nest building. 8-OH-DPAT did not affect these behaviors. 8-OH-DPAT (1.0 mg/kg) provoked the serotonergic syndrome and hypothermia; however, ovariectomized animals showed more signs of the syndrome and a decrease in body temperature after 8-OH-DPAT than lactating rats. Buspirone, but not the other anxiolytics, reduced motor activity. The role of drugs acting at the serotonergic, dopaminergic, and GABA-benzodiazepine systems in the control of maternal behavior and aggression is discussed. Copyright (C) 2000 Elsevier Science Inc.
AB - The action of diazepam (0.0, 1.0, and 2.0 mg/kg) and the serotonergic compounds buspirone (0.0, 2.5, and 5.0 mg/kg) and 8-OH-DPAT (0.0, 0.1, and 1.0 mg/kg) on maternal behavior and aggression were studied. An activity test was made after these treatments to control for unspecific actions due to motor impairment. Diazepam and buspirone dose-dependently inhibited the expression of maternal aggression and the active components of maternal behavior such as retrieving and nest building. 8-OH-DPAT did not affect these behaviors. 8-OH-DPAT (1.0 mg/kg) provoked the serotonergic syndrome and hypothermia; however, ovariectomized animals showed more signs of the syndrome and a decrease in body temperature after 8-OH-DPAT than lactating rats. Buspirone, but not the other anxiolytics, reduced motor activity. The role of drugs acting at the serotonergic, dopaminergic, and GABA-benzodiazepine systems in the control of maternal behavior and aggression is discussed. Copyright (C) 2000 Elsevier Science Inc.
KW - 8-OH-DPAT
KW - Buspirone
KW - Diazepam
KW - Maternal aggression
KW - Maternal behavior
UR - http://www.scopus.com/inward/record.url?scp=0034083192&partnerID=8YFLogxK
U2 - 10.1016/S0091-3057(00)00211-2
DO - 10.1016/S0091-3057(00)00211-2
M3 - Artículo
SN - 0091-3057
VL - 66
SP - 389
EP - 396
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 2
ER -