TY - JOUR
T1 - Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma
AU - Suarez-Roa, M. L.
AU - Asbun-Bojalil, J.
AU - Ruiz-Godoy, L. M.
AU - Meneses-García, A. A.
PY - 2012/9
Y1 - 2012/9
N2 - Background: Several studies have shown the participation of MMPs in oral squamous cell carcinoma, the most frequent malignant neoplasm of the oral cavity. The expression of some MMPs correlates with a more aggressive biological behaviour. The objective of this study was to determine which MMPs and TIMPs were expressed in both neoplastic and peritumoural stromal cells in different histopathology areas. Methods: Patients who underwent primary tumour neck dissection for oral squamous cell carcinoma were included. Immunoexpression of MMP-1, -2, -3, -7, -9, -11, -13, and TIMP-1 and -2 in different areas of pathologic specimens (in situ carcinoma, primary tumour, invasive front, distant invasion carcinoma, and lymph node metastasis) was evaluated. Enzyme expression on mucosa adjacent to tumour served as control. Results: Thirty cases were included. Only 6 MMPs and 1 TIMP were expressed in the studied areas. Statistically significant differences in the number of cases with positive MMPs or TIMP expression, in both neoplastic and peritumoural cells, between control and the rest of the areas were observed. MMP-2 expression was constant in the areas with a more aggressive biological behaviour. Conclusions: MMP-2 expression may represent a dynamic interaction between host and tumour that favours the establishment of neoplastic cells at distant sites.
AB - Background: Several studies have shown the participation of MMPs in oral squamous cell carcinoma, the most frequent malignant neoplasm of the oral cavity. The expression of some MMPs correlates with a more aggressive biological behaviour. The objective of this study was to determine which MMPs and TIMPs were expressed in both neoplastic and peritumoural stromal cells in different histopathology areas. Methods: Patients who underwent primary tumour neck dissection for oral squamous cell carcinoma were included. Immunoexpression of MMP-1, -2, -3, -7, -9, -11, -13, and TIMP-1 and -2 in different areas of pathologic specimens (in situ carcinoma, primary tumour, invasive front, distant invasion carcinoma, and lymph node metastasis) was evaluated. Enzyme expression on mucosa adjacent to tumour served as control. Results: Thirty cases were included. Only 6 MMPs and 1 TIMP were expressed in the studied areas. Statistically significant differences in the number of cases with positive MMPs or TIMP expression, in both neoplastic and peritumoural cells, between control and the rest of the areas were observed. MMP-2 expression was constant in the areas with a more aggressive biological behaviour. Conclusions: MMP-2 expression may represent a dynamic interaction between host and tumour that favours the establishment of neoplastic cells at distant sites.
KW - Oral cavity
KW - immunoexpression
KW - matrix metalloproteinases
KW - peritumoural cells
KW - squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84865711012&partnerID=8YFLogxK
U2 - 10.1111/j.1834-7819.2012.01705.x
DO - 10.1111/j.1834-7819.2012.01705.x
M3 - Artículo
C2 - 22924352
SN - 0045-0421
VL - 57
SP - 300
EP - 307
JO - Australian Dental Journal
JF - Australian Dental Journal
IS - 3
ER -