TY - JOUR
T1 - Hydrogels for cartilage regeneration, from polysaccharides to hybrids
AU - Sánchez-Téllez, Daniela Anahí
AU - Téllez-Jurado, Lucía
AU - Rodríguez-Lorenzo, Luís María
N1 - Publisher Copyright:
© 2017 by the authors.
PY - 2017/12/4
Y1 - 2017/12/4
N2 - The aims of this paper are: (1) to review the current state of the art in the field of cartilage substitution and regeneration; (2) to examine the patented biomaterials being used in preclinical and clinical stages; (3) to explore the potential of polymeric hydrogels for these applications and the reasons that hinder their clinical success. The studies about hydrogels used as potential biomaterials selected for this review are divided into the two major trends in tissue engineering: (1) the use of cell-free biomaterials; and (2) the use of cell seeded biomaterials. Preparation techniques and resulting hydrogel properties are also reviewed. More recent proposals, based on the combination of different polymers and the hybridization process to improve the properties of these materials, are also reviewed. The combination of elements such as scaffolds (cellular solids), matrices (hydrogel-based), growth factors and mechanical stimuli is needed to optimize properties of the required materials in order to facilitate tissue formation, cartilage regeneration and final clinical application. Polymer combinations and hybrids are the most promising materials for this application. Hybrid scaffolds may maximize cell growth and local tissue integration by forming cartilage-like tissue with biomimetic features.
AB - The aims of this paper are: (1) to review the current state of the art in the field of cartilage substitution and regeneration; (2) to examine the patented biomaterials being used in preclinical and clinical stages; (3) to explore the potential of polymeric hydrogels for these applications and the reasons that hinder their clinical success. The studies about hydrogels used as potential biomaterials selected for this review are divided into the two major trends in tissue engineering: (1) the use of cell-free biomaterials; and (2) the use of cell seeded biomaterials. Preparation techniques and resulting hydrogel properties are also reviewed. More recent proposals, based on the combination of different polymers and the hybridization process to improve the properties of these materials, are also reviewed. The combination of elements such as scaffolds (cellular solids), matrices (hydrogel-based), growth factors and mechanical stimuli is needed to optimize properties of the required materials in order to facilitate tissue formation, cartilage regeneration and final clinical application. Polymer combinations and hybrids are the most promising materials for this application. Hybrid scaffolds may maximize cell growth and local tissue integration by forming cartilage-like tissue with biomimetic features.
KW - Cartilage regeneration
KW - Hybrid hydrogels
KW - Hybrid scaffolds
KW - Polymeric hydrogels
KW - Polysaccharides
UR - http://www.scopus.com/inward/record.url?scp=85037142417&partnerID=8YFLogxK
U2 - 10.3390/polym9120671
DO - 10.3390/polym9120671
M3 - Artículo de revisión
SN - 2073-4360
VL - 9
JO - Polymers
JF - Polymers
IS - 12
M1 - 671
ER -