TY - JOUR
T1 - Holoprosencefalia
T2 - Análise do seu espectro morfológico em doze casos de autópsia
AU - De Noronha, Lúcia
AU - Ghanem, Ramon Coral
AU - Medeiros, Fabíola
AU - Knopfholz, José
AU - Magalhães, Tiago Augusto
AU - Sampaio, Gilberto Antunes
AU - Serapião, Maria José
AU - Torres, Luiz Fernando Bleggi
PY - 2001/12
Y1 - 2001/12
N2 - The term holoprosencephaly (HPC) is used to indicate the group of hemispheric deformities caused by a failure in the development of the prosencephalic vesicle. The purpose of this study is to explain the morphologic specter of twelve cases of HPC, qualify them, and compare them to the literature. It was evaluated 5837 pediatrics necropsies, and there were 12 cases of HPC. Data like gender, age and the presence of another associated malformations were evaluated and compared to another malformations and to the total number of necropsies. The majority of the cases was male (66.66%), and stillborns (75%). The most frequently type of HPC found was the lobar type (58.3%), and the most frequently type of facial alteration was the ciclopy (25%). There is a statistic tendency to HPC affect the male sex, in comparison with other neurologic malformations. Besides, the stillborns are more frequently observed in HPC than in other neurologic malformations.
AB - The term holoprosencephaly (HPC) is used to indicate the group of hemispheric deformities caused by a failure in the development of the prosencephalic vesicle. The purpose of this study is to explain the morphologic specter of twelve cases of HPC, qualify them, and compare them to the literature. It was evaluated 5837 pediatrics necropsies, and there were 12 cases of HPC. Data like gender, age and the presence of another associated malformations were evaluated and compared to another malformations and to the total number of necropsies. The majority of the cases was male (66.66%), and stillborns (75%). The most frequently type of HPC found was the lobar type (58.3%), and the most frequently type of facial alteration was the ciclopy (25%). There is a statistic tendency to HPC affect the male sex, in comparison with other neurologic malformations. Besides, the stillborns are more frequently observed in HPC than in other neurologic malformations.
KW - Autopsy
KW - Holoprosencephaly
KW - Nervous system malformations
UR - http://www.scopus.com/inward/record.url?scp=0035650607&partnerID=8YFLogxK
U2 - 10.1590/s0004-282x2001000600014
DO - 10.1590/s0004-282x2001000600014
M3 - Artículo
SN - 0004-282X
VL - 59
SP - 913
EP - 919
JO - Arquivos de Neuro-Psiquiatria
JF - Arquivos de Neuro-Psiquiatria
IS - 4
ER -