TY - JOUR
T1 - Experimental animal models of central nervous system tuberculosis
T2 - A historical review
AU - Sánchez-Garibay, Carlos
AU - Hernández-Campos, María Elena
AU - Tena-Suck, Martha Lilia
AU - Salinas-Lara, Citlaltepetl
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/5
Y1 - 2018/5
N2 - Animal models are and will remain valuable tools in medical research because their use enables a deeper understanding of disease development, thus generating important knowledge for developing disease control strategies. Central nervous system tuberculosis (CNS TB) is the most devastating disease in humans. Moreover, as the variability of signs and symptoms delay a timely diagnosis, patients usually arrive at the hospital suffering from late stage disease. Therefore, it is impossible to obtain fresh human tissue for research before an autopsy. Because of these reasons, studies on human CNS TB are limited to case series, pharmacological response reports, and post mortem histopathological studies. Here, we review the contribution of the different animal models to understand the immunopathology of the disease and the host-parasitic relationship, as well as in the development of new strategies of vaccination and to test new drugs for the treatment of CNS TB.
AB - Animal models are and will remain valuable tools in medical research because their use enables a deeper understanding of disease development, thus generating important knowledge for developing disease control strategies. Central nervous system tuberculosis (CNS TB) is the most devastating disease in humans. Moreover, as the variability of signs and symptoms delay a timely diagnosis, patients usually arrive at the hospital suffering from late stage disease. Therefore, it is impossible to obtain fresh human tissue for research before an autopsy. Because of these reasons, studies on human CNS TB are limited to case series, pharmacological response reports, and post mortem histopathological studies. Here, we review the contribution of the different animal models to understand the immunopathology of the disease and the host-parasitic relationship, as well as in the development of new strategies of vaccination and to test new drugs for the treatment of CNS TB.
KW - Animal models
KW - Central nervous system tuberculosis
KW - Experimental tuberculosis
KW - Immunopathology
UR - http://www.scopus.com/inward/record.url?scp=85043474693&partnerID=8YFLogxK
U2 - 10.1016/j.tube.2018.02.007
DO - 10.1016/j.tube.2018.02.007
M3 - Artículo de revisión
C2 - 29779764
SN - 1472-9792
VL - 110
SP - 1
EP - 6
JO - Tuberculosis
JF - Tuberculosis
ER -