TY - JOUR
T1 - In vitro antiparasitic and antibacterial evaluation of organic extracts of Salvadoran flora
AU - Núñez, Marvin J.
AU - Paz-González, Alma D.
AU - Vázquez-Jiménez, Lenci K.
AU - Castillo, Ulises G.
AU - Moo-Puc, Rosa
AU - Chan-Bacab, Jesús M.
AU - Aguilera-Arreola, Guadalupe
AU - Catalán-Gonzalez, Lucero
AU - Quintana-Gómez, Alexis Uriel
AU - Castañeda-Sánchez, Jorge Ismael
AU - Luna-Herrera, Julieta
AU - Rivera, Gildardo
N1 - Publisher Copyright:
© 2023, MS-Editions. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Currently, in developing countries, parasitic and bacterial diseases as amebiasis, giardiasis, trichonomiasis, leishmaniasis, trypanosomiasis, tuberculosis, and nocardiasis are a public health problem. The pharmacological treatment for these diseases is not completely effective and causes several side effects in patients. Therefore, the search for new compounds with biological activity is very important to develop new drugs safely and more efficiently. In this study, different organic extracts obtained from thirty-seven species of the Salvadoran flora were evaluated in several in vitro models to determine their potential activity against five protozoa (Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Leishmania mexicana, and Trypanosoma cruzi) and three bacteria (Acinetobacter baumanni, Mycobacterium tuberculosis, and Nocardia brasiliensis). The results showed the activity of eight extracts with IC50 values of less than 100 μg/mL against L. mexicana and five extracts with MICs values less than <50 μg/mL against M. tuberculosis. Besides, seven plant species showed MICs ≤3.125 μg/mL against N. brasiliensis. Additionally, secondary metabolites (flavonoids and monoterpene oxygenate) previously reported as active were fingerprint by UPLC-MS to establish a potential correlation with the biological activity showed.
AB - Currently, in developing countries, parasitic and bacterial diseases as amebiasis, giardiasis, trichonomiasis, leishmaniasis, trypanosomiasis, tuberculosis, and nocardiasis are a public health problem. The pharmacological treatment for these diseases is not completely effective and causes several side effects in patients. Therefore, the search for new compounds with biological activity is very important to develop new drugs safely and more efficiently. In this study, different organic extracts obtained from thirty-seven species of the Salvadoran flora were evaluated in several in vitro models to determine their potential activity against five protozoa (Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Leishmania mexicana, and Trypanosoma cruzi) and three bacteria (Acinetobacter baumanni, Mycobacterium tuberculosis, and Nocardia brasiliensis). The results showed the activity of eight extracts with IC50 values of less than 100 μg/mL against L. mexicana and five extracts with MICs values less than <50 μg/mL against M. tuberculosis. Besides, seven plant species showed MICs ≤3.125 μg/mL against N. brasiliensis. Additionally, secondary metabolites (flavonoids and monoterpene oxygenate) previously reported as active were fingerprint by UPLC-MS to establish a potential correlation with the biological activity showed.
KW - Infectious diseases
KW - Micetoma
KW - Protozoa
KW - Secondary metabolites
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85137567192&partnerID=8YFLogxK
U2 - 10.37360/blacpma.23.22.1.2
DO - 10.37360/blacpma.23.22.1.2
M3 - Artículo
AN - SCOPUS:85137567192
SN - 0717-7917
VL - 22
SP - 19
EP - 36
JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
JF - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
IS - 1
ER -
