TY - JOUR
T1 - (−)-Epicatechin improves body composition of male rats descendant of obese mothers postnatally fed with a high-fat diet
AU - De los Santos, Sergio
AU - Coral-Vázquez, Ramón Mauricio
AU - Menjivar, Marta
AU - de los Ángeles Granados-Silvestre, María
AU - De la Rosa, Sebastián
AU - Reyes-Castro, Luis Antonio
AU - Méndez, Juan Pablo
AU - Zambrano, Elena
AU - Canto, Patricia
N1 - Publisher Copyright:
© 2022 Société Française de Pharmacologie et de Thérapeutique.
PY - 2022/6
Y1 - 2022/6
N2 - A combination of maternal obesity and high-fat diet (HFD) in offspring postnatal life has deleterious effects, and (−)-epicatechin (Epi) treatment can reverse these adverse effects. To investigate whether Epi administration can modify fat mass, muscle mass, and bone mass in male rats descended from obese mothers, fed postnatally on an HFD. Male offspring of mothers fed with control diet formed the control group (C), control group with high-fat diet (CHF), and control group with high-fat diet + epicatechin (CHF + Epi). Male offspring of maternal obesity formed the group with control diet (MO), maternal obesity group with high-fat diet (MOHF), and maternal obesity group with high-fat diet + epicatechin (MOHF + Epi). We measured total fat and weight of visceral adipose tissue by dissection and by dual-energy x-ray absorptiometry scanning body composition. Epicatechin diminished total and visceral pads fat of male offspring of CHF + Epi and MOHF + Epi groups versus to male offspring of CHF and MOHF groups. Besides, epicatechin increased lean mass in CHF + Epi and MOHF + Epi groups, but these changes were not significant. Total body mineral density of the male offspring of CHF, MOHF, and MOHF + Epi groups was significantly higher versus male offspring of C and MO groups. Obesity programming model plus a high-fat postnatal diet presents higher visceral adipose tissue, decreased lean mass, and modified body mineral density when compared with a direct obesity model and its controls. Epicatechin treatment improved body composition; however, it was not able to induce similar values as presented by the controls.
AB - A combination of maternal obesity and high-fat diet (HFD) in offspring postnatal life has deleterious effects, and (−)-epicatechin (Epi) treatment can reverse these adverse effects. To investigate whether Epi administration can modify fat mass, muscle mass, and bone mass in male rats descended from obese mothers, fed postnatally on an HFD. Male offspring of mothers fed with control diet formed the control group (C), control group with high-fat diet (CHF), and control group with high-fat diet + epicatechin (CHF + Epi). Male offspring of maternal obesity formed the group with control diet (MO), maternal obesity group with high-fat diet (MOHF), and maternal obesity group with high-fat diet + epicatechin (MOHF + Epi). We measured total fat and weight of visceral adipose tissue by dissection and by dual-energy x-ray absorptiometry scanning body composition. Epicatechin diminished total and visceral pads fat of male offspring of CHF + Epi and MOHF + Epi groups versus to male offspring of CHF and MOHF groups. Besides, epicatechin increased lean mass in CHF + Epi and MOHF + Epi groups, but these changes were not significant. Total body mineral density of the male offspring of CHF, MOHF, and MOHF + Epi groups was significantly higher versus male offspring of C and MO groups. Obesity programming model plus a high-fat postnatal diet presents higher visceral adipose tissue, decreased lean mass, and modified body mineral density when compared with a direct obesity model and its controls. Epicatechin treatment improved body composition; however, it was not able to induce similar values as presented by the controls.
KW - (−)-epicatechin
KW - bone density
KW - fat mass
KW - high-fat diet
KW - maternal obesity
KW - muscle mass
UR - http://www.scopus.com/inward/record.url?scp=85122741259&partnerID=8YFLogxK
U2 - 10.1111/fcp.12749
DO - 10.1111/fcp.12749
M3 - Artículo
C2 - 34984750
AN - SCOPUS:85122741259
SN - 0767-3981
VL - 36
SP - 526
EP - 535
JO - Fundamental and Clinical Pharmacology
JF - Fundamental and Clinical Pharmacology
IS - 3
ER -