TY - JOUR
T1 - Eosinophilia in Preterm Born Infants Infected with Chlamydia trachomatis
AU - López-Hurtado, Marcela
AU - Arteaga-Troncoso, Gabriel
AU - Sosa-González, Irma E.
AU - de Haro-Cruz, Maria de Jesus
AU - Flores-Salazar, Veronica R.
AU - Guerra-Infante, Fernando Martín
N1 - Publisher Copyright:
© 2016 Taylor & Francis Group, LLC.
PY - 2016/5/3
Y1 - 2016/5/3
N2 - A higher than 350 eosinophils/mm3 is strongly associated with Chlamydia trachomatis in term born babies coursing with respiratory distress. However, in preterm newborns infected with this pathogen, the levels of eosinophils are unknown. Forty newborn infants with clinical data of respiratory problems and/or sepsis were analyzed. DNA of leukocytes from peripheral blood was used to identify C. trachomatis. Detection of chlamydial infection was performed by amplifying the ompA gene by an in-house PCR, and eosinophil levels were evaluated in an XT-2000-hematology analyzer. Eighteen infants showed chlamydial infection and 14 of them showed pneumonia (RR = 2.6; CI95% 1.03-6.5; p =.027). Their eosinophil levels were 719 ± 614 cells/mm3. A significant association between eosinophilia ≥1250 cells/mm3 and gestational age of less than 29 weeks (RR = 5.8; 1.35; CI95% [1.4-24.5], p <.008) was observed. The preterm infants with chlamydial infection did not show higher eosinophil levels than uninfected infants.
AB - A higher than 350 eosinophils/mm3 is strongly associated with Chlamydia trachomatis in term born babies coursing with respiratory distress. However, in preterm newborns infected with this pathogen, the levels of eosinophils are unknown. Forty newborn infants with clinical data of respiratory problems and/or sepsis were analyzed. DNA of leukocytes from peripheral blood was used to identify C. trachomatis. Detection of chlamydial infection was performed by amplifying the ompA gene by an in-house PCR, and eosinophil levels were evaluated in an XT-2000-hematology analyzer. Eighteen infants showed chlamydial infection and 14 of them showed pneumonia (RR = 2.6; CI95% 1.03-6.5; p =.027). Their eosinophil levels were 719 ± 614 cells/mm3. A significant association between eosinophilia ≥1250 cells/mm3 and gestational age of less than 29 weeks (RR = 5.8; 1.35; CI95% [1.4-24.5], p <.008) was observed. The preterm infants with chlamydial infection did not show higher eosinophil levels than uninfected infants.
KW - Chlamydia trachomatis
KW - eosinophilia
KW - pneumonia
KW - preterm newborn
KW - sepsis
UR - http://www.scopus.com/inward/record.url?scp=84962909874&partnerID=8YFLogxK
U2 - 10.3109/15513815.2016.1153175
DO - 10.3109/15513815.2016.1153175
M3 - Artículo
C2 - 27064841
SN - 1551-3815
VL - 35
SP - 149
EP - 158
JO - Fetal and Pediatric Pathology
JF - Fetal and Pediatric Pathology
IS - 3
ER -