TY - JOUR
T1 - Effects of ethanol administration on hepatocellular ultrastructure of regenerating liver induced by partial hepatectomy
AU - Morales-González, José A.
AU - Jiménez-García, Luis F.
AU - Gutiérrez-Salinas, José
AU - Sepúlveda, Jorge
AU - Leija-Salas, Alfonso
AU - Hernández-Muñoz, Rolando
N1 - Funding Information:
This work was partially supported by a grant from the Consejo Nacional de Ciencia y Tecnología (CONACyT # 25431-M), and from the DGAPA-PAPIIT (IN 203597). J.A.M.G. is a postdoctoral fellow from CONACyT and from the DGEP-UNAM.
PY - 2001
Y1 - 2001
N2 - Acute ethanol administration partially inhibits DNA and protein syntheses during liver regeneration (LR) induced by partial hepatectomy (PH) in rats. Previous findings that the magnitude of ethanol's deleterious effects on LR are related to the route and timing of its administration led us to perform studies at the ultrastructural level, comparing ethanol effects on PH-induced LR, as a consequence of its administration route. PH promoted alterations on the endoplasmic reticulum and mitochondria, accompanied by decreased glycogen and increased lipid content in cytoplasm. Structural nuclear and nucleolar activities were also evident. Intragastric ethanol administration practically abolished the adaptative changes found in PH-promoted regenerating hepatocytes, whereas its administration through the intraperitoneal route induced later ultrastructural modifications, indicating cellular proliferation. These results suggest that ethanol, under certain conditions, could stimulate liver proliferation triggered by PH. The mechanism underlying this surprising effect of ethanol on LR remains to be elucidated. However, it is suggested that an altered ethanol metabolism by rats subjected to PH could be involved.
AB - Acute ethanol administration partially inhibits DNA and protein syntheses during liver regeneration (LR) induced by partial hepatectomy (PH) in rats. Previous findings that the magnitude of ethanol's deleterious effects on LR are related to the route and timing of its administration led us to perform studies at the ultrastructural level, comparing ethanol effects on PH-induced LR, as a consequence of its administration route. PH promoted alterations on the endoplasmic reticulum and mitochondria, accompanied by decreased glycogen and increased lipid content in cytoplasm. Structural nuclear and nucleolar activities were also evident. Intragastric ethanol administration practically abolished the adaptative changes found in PH-promoted regenerating hepatocytes, whereas its administration through the intraperitoneal route induced later ultrastructural modifications, indicating cellular proliferation. These results suggest that ethanol, under certain conditions, could stimulate liver proliferation triggered by PH. The mechanism underlying this surprising effect of ethanol on LR remains to be elucidated. However, it is suggested that an altered ethanol metabolism by rats subjected to PH could be involved.
KW - Alcohol
KW - Cell proliferation
KW - Ethanol metabolism
KW - Nuclear activity
KW - Nucleolus
UR - http://www.scopus.com/inward/record.url?scp=0035078956&partnerID=8YFLogxK
U2 - 10.1023/A:1005613201809
DO - 10.1023/A:1005613201809
M3 - Artículo
SN - 0163-2116
VL - 46
SP - 360
EP - 369
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 2
M1 - 300307
ER -