TY - JOUR
T1 - Differentially expressed proteins in platelets derived from patients with hypertension
AU - Armenta-Medina, Yobana
AU - Martínez-Vieyra, Ivette
AU - Medina-Contreras, Oscar
AU - Benitez-Cardoza, Claudia G.
AU - Jiménez-Pineda, Albertana
AU - Reyes-López, César A.
AU - Cerecedo, Doris
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/7
Y1 - 2022/7
N2 - Hypertension (HTN) causes end-organ damage and is a major cause of morbidity and mortality globally. Recent studies suggested blood cells participate in the maintenance of HTN. Platelets—anucleated cell fragments derived from megakaryocytes—exert diverse functions, including their well-characterized role in the formation of hemostatic clots. However, platelets from patients with HTN exhibit altered membrane lipid and protein compositions that impact platelet function and lead to formation of aggregates and vascular obstructions. Here, for the first time, we have identified, by proteomic analyses, the most relevant 11 proteins that show the greatest difference in their expression in platelets derived from patients with HTN, in comparison with those from normotensive individuals. These proteins are involved in cytoskeletal organization and the coagulation cascade that contributes to platelet activation, release of granule contents, and aggregation, which culminate in thrombus formation. These results have important implications in our understanding of the molecular mechanisms associated with the development of HTN, and in consequence, the development of new strategies to counteract the cardiovascular disorders associated with constitutive activation of platelets in HTN.
AB - Hypertension (HTN) causes end-organ damage and is a major cause of morbidity and mortality globally. Recent studies suggested blood cells participate in the maintenance of HTN. Platelets—anucleated cell fragments derived from megakaryocytes—exert diverse functions, including their well-characterized role in the formation of hemostatic clots. However, platelets from patients with HTN exhibit altered membrane lipid and protein compositions that impact platelet function and lead to formation of aggregates and vascular obstructions. Here, for the first time, we have identified, by proteomic analyses, the most relevant 11 proteins that show the greatest difference in their expression in platelets derived from patients with HTN, in comparison with those from normotensive individuals. These proteins are involved in cytoskeletal organization and the coagulation cascade that contributes to platelet activation, release of granule contents, and aggregation, which culminate in thrombus formation. These results have important implications in our understanding of the molecular mechanisms associated with the development of HTN, and in consequence, the development of new strategies to counteract the cardiovascular disorders associated with constitutive activation of platelets in HTN.
UR - http://www.scopus.com/inward/record.url?scp=85109251170&partnerID=8YFLogxK
U2 - 10.1038/s41371-021-00555-y
DO - 10.1038/s41371-021-00555-y
M3 - Artículo
C2 - 34218268
AN - SCOPUS:85109251170
SN - 0950-9240
VL - 36
SP - 640
EP - 650
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
IS - 7
ER -