Detection of leukemia with blood samples using raman spectroscopy and multivariate analysis

J. C. Martínez-Espinosa, J. L. González-Solís, M. L. Miranda-Beltrán, C. Soria-Fregoso, J. Medina-Valtierra, C. Frausto-Reyes

Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

7 Citas (Scopus)

Resumen

The use of Raman spectroscopy to analyze blood biochemistry and hence distinguish between normal and abnormal blood was investigated. Blood samples were obtained from 6 patients who were clinically diagnosed with leukemia and 6 healthy volunteers. The imprint was put under the microscope and several points were chosen for Raman measurement. All the spectra were collected by a confocal Raman micro-spectroscopy (Renishaw) with a NIR 830 nm laser. It is shown that the serum samples from patients with leukemia and from the control group can be discriminated when the multivariate statistical methods of principal component analysis (PCA) and linear discriminated analysis (LDA) are applied to their Raman spectra. The ratios of some band intensities were analyzed and some band ratios were significant and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman Spectroscopy could be a new technique to study the degree of damage to the bone marrow using just blood samples instead of biopsies, treatment very painful for patients.

Idioma originalInglés
Título de la publicación alojadaLaser Florence 2008 - A Bridge to the Laser Medicine World
Subtítulo de la publicación alojadaSelected Presentations at the International Laser Medicine Congress
Páginas99-103
Número de páginas5
DOI
EstadoPublicada - 2009
Publicado de forma externa
EventoInternational Laser Medicine Congress, Laser Florence 2008: A Bridge To The Laser Medicine World - Firenze, Italia
Duración: 31 oct 20081 nov 2008

Serie de la publicación

NombreAIP Conference Proceedings
Volumen1142
ISSN (versión impresa)0094-243X
ISSN (versión digital)1551-7616

Conferencia

ConferenciaInternational Laser Medicine Congress, Laser Florence 2008: A Bridge To The Laser Medicine World
País/TerritorioItalia
CiudadFirenze
Período31/10/081/11/08

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