Design and synthesis of two steroid-pyrrolo derivatives using estrone and pregnenolone as chemical tools

Several steroid-pyrrole derivatives have been prepared using different protocols; nevertheless, have some drawbacks such as the use of some reagents that have limited stability and require special conditions. The aim of study involved the synthesis of two steroid-pyrrolo-triazecin derivatives using a series of reactions that involve; cycloaddition [2 + 2], displacement of nitro group, formation of shift base, amidation/cyclization using boric acid (Method A) or carbodiimide derivative (Method B). The results showed that there is a higher yielding with the method A in comparison with the method B. In addition, chemical structure of compounds was confirmed by NMR spectroscopic data.