TY - JOUR
T1 - Design and synthesis of two Azetidin-haloperidol derivatives using some strategies
AU - Lauro, Figueroa Valverde
AU - Francisco, Díaz Cedillo
AU - Elodia, García Cervera
AU - Eduardo, Pool Gómez
AU - Maria, López Ramos
AU - Marcela, Rosas Nexticapa
AU - Lenin, Hau Heredia
AU - Beatriz, Sarabia Alcocer
PY - 2014
Y1 - 2014
N2 - In this study is reported a straight forward route for synthesis of two azetidin-haloperidol derivatives using some strategies. The first stage was achieved by the synthesis of an azetidine derivative (3) by the reaction of a haloperidol derivative (1) with chloroacetyl chloride in presence oftriethylamine. The second stage was achieved by reaction of an estradiol derivative with 1 to forma haloperidol-estradiol derivative (5) using boric acid as catalyst. Finally, the third stage involves the synthesis of a second azetidine-derivative (6) by the reaction of 5 with chloroacetyl chloride usingtriethylamine as catalyst. The structure of the compounds obtained was confirmed by elemental analysis, spectroscopy and spectrometry data. The proposed method offers some advantages such as simple procedure, low cost, and ease of workup.
AB - In this study is reported a straight forward route for synthesis of two azetidin-haloperidol derivatives using some strategies. The first stage was achieved by the synthesis of an azetidine derivative (3) by the reaction of a haloperidol derivative (1) with chloroacetyl chloride in presence oftriethylamine. The second stage was achieved by reaction of an estradiol derivative with 1 to forma haloperidol-estradiol derivative (5) using boric acid as catalyst. Finally, the third stage involves the synthesis of a second azetidine-derivative (6) by the reaction of 5 with chloroacetyl chloride usingtriethylamine as catalyst. The structure of the compounds obtained was confirmed by elemental analysis, spectroscopy and spectrometry data. The proposed method offers some advantages such as simple procedure, low cost, and ease of workup.
KW - Azetidin-haloperidol derivatives
KW - Elemental analysis
KW - Spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84912064770&partnerID=8YFLogxK
U2 - 10.13005/ojc/300305
DO - 10.13005/ojc/300305
M3 - Artículo
SN - 0970-020X
VL - 30
SP - 947
EP - 952
JO - Oriental Journal of Chemistry
JF - Oriental Journal of Chemistry
IS - 3
ER -