TY - JOUR
T1 - Design and synthesis of two azete-phenylene-dibenzoic acid derivatives and theoretical evaluation of their interaction with BRCA-1 protein
AU - Lauro, Figueroa Valverde
AU - Francisco, Diaz Cedillo
AU - Marcela, Rosas Nexticapa
AU - Virginia, Mateu Armand
AU - Elizabeth, Montano Tapia
AU - Lenin, Hau Heredia
AU - Maria, Lopez Ramos
AU - Elodia, García Cervera
AU - Eduardo, Pool Gómez
AU - Rolando, García Martinez
AU - Raquel, Estrella Barrón
AU - Regina, Cauich Carrillo
AU - Alondra, Alfonso Jimenez
AU - Jhair, Cabrera Tuz
N1 - Publisher Copyright:
© 2018 by the authors.
PY - 2018/8/15
Y1 - 2018/8/15
N2 - Several compounds have been prepared to the treatment of breast cancer; however, some of these drugs may produce some adverse effects. The objective of this investigation carried out the synthesis of two azete-phenylene-dibenzoic acid derivatives (compounds 4 or 5) and analyze its theoretical interaction with the BRCA-1 protein surface. The preparation of 4 and 5 was carried out using a series of reactions which involves; i) addition (2 + 2); ii) etherification and iii) formation of allylamino groups. Chemical structure of azete derivatives was carried out using elemental analysis and nuclear magnetic resonance spectra. The following stage involved the theoretical evaluation of the interaction of both compounds 7 or 8 with BRCA-1 protein surface using a docking model. The results showed that compound 4 could bound to the different type of aminoacid residues of BRCA-1 protein compared with 5. All these data indicate that both compounds could be an alternative therapy for treatment of breast cancer via BRCA-1 protein inhibition.
AB - Several compounds have been prepared to the treatment of breast cancer; however, some of these drugs may produce some adverse effects. The objective of this investigation carried out the synthesis of two azete-phenylene-dibenzoic acid derivatives (compounds 4 or 5) and analyze its theoretical interaction with the BRCA-1 protein surface. The preparation of 4 and 5 was carried out using a series of reactions which involves; i) addition (2 + 2); ii) etherification and iii) formation of allylamino groups. Chemical structure of azete derivatives was carried out using elemental analysis and nuclear magnetic resonance spectra. The following stage involved the theoretical evaluation of the interaction of both compounds 7 or 8 with BRCA-1 protein surface using a docking model. The results showed that compound 4 could bound to the different type of aminoacid residues of BRCA-1 protein compared with 5. All these data indicate that both compounds could be an alternative therapy for treatment of breast cancer via BRCA-1 protein inhibition.
KW - Azete-phenylene-dibenzoic acid derivatives
KW - BRCA-1 protein
KW - Breast cancer
KW - Protein inhibition
UR - http://www.scopus.com/inward/record.url?scp=85052379081&partnerID=8YFLogxK
M3 - Artículo
SN - 2069-5837
VL - 8
SP - 3412
EP - 3417
JO - Biointerface Research in Applied Chemistry
JF - Biointerface Research in Applied Chemistry
IS - 4
ER -