Design and synthesis of new pirrol-indol derivative with positive inotropic activity

There are studies which indicate that some heterocyclic derivatives have inotropic effect; nevertheless, its inotropic activity is very confusing perhaps to difference in the chemical structure. In order, to clarify these phenomena in this study, some pirrol-indol derivatives (compounds 3, 4, 5 and 6) were synthesized with the objective of to evaluate its biological activity using a biological model. The results indicate that only the compound 4 induce a positive inotropic activity in comparison with the compound 3, 5 and 6. This datasuggest that the different groups involved in the chemical structure of 4 arethe responsible of its positive inotropic activity. In addition, this phenomenon its conditioned by some physicochemical parameters such as LogP, σ, V_m, R_m, P_c and S_t , which are cumulative effects of the different intra-and intermolecularforces involved in the structural chemistry of the compound 4.