TY - JOUR
T1 - Design and synthesis of naphthol derivative
AU - Figueroa-Valverde, Lauro
AU - Díaz-Cedillo, F.
AU - García-Cervera, E.
AU - Gómez, E. Pool
AU - Rosas-Nexticapan, Marcela
AU - Ramos-López, M.
PY - 2013
Y1 - 2013
N2 - In this study a naphthalene derivative was synthetized using several strategies; in first stage a steroid derivative (3) was development by the reaction between androsterone and ethylenediamine using boric acid as catalyst. In the second stage compound 3 was used in the three-component system (β-naphthol, benzaldehyde and compound 3) for the synthesis of 17-(2-[[(2-hydroxy-naphtalen-1-yl)-phenyl-methyl] amino]ethylamino)-10,13- dimethyl-2,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a] -phenanthren-3-ol (6). In addition, a second method was used to form 6. In this technique 1-[(2-amino-ethylamino)-phenyl-methyl]-naphthalen-2-ol was made reacting with androsterone to form 6 using boric acid as catalyst. The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods.
AB - In this study a naphthalene derivative was synthetized using several strategies; in first stage a steroid derivative (3) was development by the reaction between androsterone and ethylenediamine using boric acid as catalyst. In the second stage compound 3 was used in the three-component system (β-naphthol, benzaldehyde and compound 3) for the synthesis of 17-(2-[[(2-hydroxy-naphtalen-1-yl)-phenyl-methyl] amino]ethylamino)-10,13- dimethyl-2,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a] -phenanthren-3-ol (6). In addition, a second method was used to form 6. In this technique 1-[(2-amino-ethylamino)-phenyl-methyl]-naphthalen-2-ol was made reacting with androsterone to form 6 using boric acid as catalyst. The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods.
KW - Benzaldehyde androsterone and ethylenediamine
KW - β-Naphthol
UR - http://www.scopus.com/inward/record.url?scp=84880061580&partnerID=8YFLogxK
U2 - 10.14233/ajchem.2013.14489
DO - 10.14233/ajchem.2013.14489
M3 - Artículo
SN - 0970-7077
VL - 25
SP - 6724
EP - 6726
JO - Asian Journal of Chemistry
JF - Asian Journal of Chemistry
IS - 12
ER -